GCGR Antibody

Datasheet
Code CSB-PA002705
Size US$167
Uniprot No. P47871
Image
  • Western Blot analysis of COLO205 cells using Glucagon Receptor Polyclonal Antibody
  • Western Blot analysis of COLO205 cells using Glucagon Receptor Polyclonal Antibody
Immunogen Synthesized peptide derived from the Internal region of Human Glucagon Receptor.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications WB,IF,ELISA;WB:1/500-1/2000.IF:1/200-1/1000.ELISA:1/5000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias GCGR; Glucagon receptor; GL-R
Immunogen Species Homo sapiens (Human)
Protocols Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
Target Names GCGR
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 2 family
Database Links

HGNC: 4192

OMIM: 138033

KEGG: hsa:2642

STRING: 9606.ENSP00000383558

UniGene: Hs.208

Pathway Glucagon signaling pathway

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