GNAI2 Antibody

1. The data show that the nonpalmitoylated CB1 receptor significantly reduced its association with Galphai2 . PMID: 28722168
2. MicroRNA-222-3p/GNAI2/AKT signaling axis inhibits epithelial ovarian cancer cell growth and is associated with good overall survival. PMID: 27811362
3. Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing. PMID: 26662512
4. Data strongly implicate GNAI2 as a critical regulator of oncogenesis and an upstream driver of cancer progression in ovarian carcinoma. PMID: 24423449
5. Galpha(i2) activates the TRPC4 channel by direct binding. PMID: 25788576
6. Changes in ion selectivity and pore dilation of the TRPC4 channel elicited by the Galphai2 subunit, were studied. PMID: 24011658
7. Galphai2(Q205L) regulates satellite cell differentiation into myotubes in a protein kinase C - and histone deacetylase -dependent manner PMID: 24298018
8. There is an interaction between the activated Gsalpha subunit and membrane lipid microdomains in the pathophysiology of some major depressive disorders. PMID: 23490066
9. These results suggest that the extent of G-protein-mediated inhibition is significantly reduced in the K1336E mutant CaV2.1 Ca(2+) channels PMID: 23430985
10. The ubiquitination of Galphai2 and Galphaq is suppressed by expression of Ric-8A. The suppression likely requires Ric-8A interaction with these Galpha proteins; the C-terminal truncation of Galphaq and Galphai2 completely abrogates their interaction with Ric-8A. PMID: 23665327
11. Gialpha2 plays an essential role in OXT and EGF signaling to induce prostate cancer cell migration. PMID: 22936789
12. HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Galpha(i2) for degradation through ubiquitination PMID: 23071112
13. Galphai2 as a novel claudin-5 partner required for TJ integrity in brain endothelial cells. PMID: 22333621
14. Suggest that Gnia2 is involved in endothelial TLR pathways along a signaling cascade that is distinct from MyD88. PMID: 21949112
15. SDF-1 treatment of T cells induced the formation of a novel molecular signaling complex containing RasGRP1, Galphai2, and ZAP-70. PMID: 21856938
16. Study identified a number of high-confident miR-138 target genes, including proto-oncogene GNAI2, which may play an important role in tongue squamous cell carcinoma. initiation and progression. PMID: 21079996
17. CXCL12 upregulated T-cell activation, and an alpha(i) G-coupled protein mediated signaling pathway was necessary for stimulation of T cells by CXCL12. PMID: 12088413
18. Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2 PMID: 12359238
19. valproic acid-induced expression of Galphai2 is regulated by Sp1 transcription factor PMID: 12624107
20. Cholesterol lowering by pravastatin might increase the response of the heart to parasympathetic stimulation and changes in Galpha(i2) expression might serve as a molecular marker for this effect PMID: 14623802
21. Galphai2 has a role in calcium-sensing receptor-mediated ERK1/2 activation PMID: 14701866
22. Abnormal regulation of GNAI2 was studied in cultured skin fibroblasts from insulin-resistant hypertensive individuals. PMID: 15126921
23. in elderly subjects of similar ages, those with diabetes have 1.7-fold higher levels of Galpha(i2) and twofold higher levels of Gbeta(1). PMID: 15331550
24. the Galphai2 gene promoter is transcriptionally activated through nuclear factor-kappaB and antioxidant response elements PMID: 15640523
25. a GNAI2 -318 C>G SNP impairs transcriptional activity through specific binding of Sp1 and is associated with high SBP in Caucasians from Italy PMID: 16565233
26. These results suggest that Galphai2 is involved specifically in the activation of TRPC4. PMID: 18854172
27. These results show that G(i2) protein is involved in D(2)R-mediated ERK activation but beta-arrestins 1 and 2 are either not involved or play minor role. PMID: 18940181
28. This suggests a novel set of candidate genes for NS (GNAI2 and RGS proteins) and if validated could have important implications for therapy as well. PMID: 19282110
29. Data support the notion that oligomerization of the mu-opioid receptor is not required for agonist and antagonist binding in regard to allosteric regulation of agonist binding by Gi2. PMID: 19542234

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HGNC: 4385

OMIM: 139360

KEGG: hsa:2771

STRING: 9606.ENSP00000312999

UniGene: Hs.77269