GRPEL1 Antibody

Code CSB-PA009941GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
GRPEL1
Alternative Names
FLJ25609 antibody; GREPEL 1 antibody; GREPEL1 antibody; GrpE like 1 antibody; GrpE like 1 mitochondrial antibody; GrpE like protein cochaperone antibody; GrpE protein homolog 1 mitochondrial antibody; GrpE protein homolog 1; mitochondrial antibody; GRPE1_HUMAN antibody; GRPEL 1 antibody; Grpel1 antibody; HMGE antibody; Mt GrpE#1 antibody; Mt-GrpE#1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human GRPEL1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.
Gene References into Functions
  1. Data suggest that two putative NEF (nucleotide exchange factors) orthologs, GRPEL1 and GRPEL2, modulate function of mitochondrial HSP70 (mtHSP70); both GRPEL1 and GRPEL2 associate with mtHSP70 as hetero-oligomeric subcomplex and regulate mtHSP70 transport. (GRPEL = mitochondrial GrpE-like protein; HSP70 = heat-shock protein 70) PMID: 28848044
  2. The low resolution structure of human GrpE presented suggests that GrpE is a symmetric dimer when not bound to DnaK PMID: 12840016
Subcellular Location
Mitochondrion matrix.
Protein Families
GrpE family
Database Links

HGNC: 19696

OMIM: 606173

KEGG: hsa:80273

STRING: 9606.ENSP00000264954

UniGene: Hs.443723

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