ICA1 Antibody

Datasheet

Code	CSB-PA12109A0Rb
Size	US$166
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Image	Western blot All lanes: ICA1 antibody at 2µg/ml + A549 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 55, 58 kDa Observed band size: 55 kDa Western Blot Positive WB detected in: Mouse brain tissue All lanes: ICA1 antibody at 4µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 55, 58 kDa Observed band size: 55 kDa Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA12109A0Rb at dilution of 1:50
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ICA1 Polyclonal antibody

Uniprot No.

Q05084

Target Names

ICA1

Alternative Names

69 kDa islet cell autoantigen antibody; Diabetes mellitus type I autoantigen antibody; ICA 1 antibody; Ica1 antibody; ICA69 antibody; ICA69_HUMAN antibody; ICAp69 antibody; Islet cell autoantigen 1 (69kD) antibody; Islet cell autoantigen 1 69kDa antibody; Islet cell autoantigen 1 antibody; Islet cell autoantigen 1 isoform antibody; Islet cell autoantigen p69 antibody; OTTHUMP00000200933 antibody; OTTHUMP00000200934 antibody; OTTHUMP00000200941 antibody; OTTHUMP00000200993 antibody; p69 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Islet cell autoantigen 1 protein (1-268AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ICA1 Antibody (Product code: CSB-PA12109A0Rb) is Non-conjugated. For ICA1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA12109B0Rb	ICA1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA12109C0Rb	ICA1 Antibody, FITC conjugated
Biotin	CSB-PA12109D0Rb	ICA1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

May play a role in neurotransmitter secretion.

Gene References into Functions

C-terminal domain of ICA69 interacts with PICK1 and acts on trafficking of PICK1-PKCalpha complex and cerebellar plasticity. PMID: 24358315
Novel association was found between intraocular pressure and a common variant at 7p21 near to GLCCI1 and ICA1. PMID: 23836780
polymorphisms within the NOD Ica1 core promoter may determine AIRE-mediated down-regulation of ICA69 expression in medullary thymic epithelial cells. PMID: 22447927
The exon A promoter exhibits greater activity in islet cells, whereas the exon B promoter more efficiently activates transcription in neuronal cells. PMID: 12409289
ICA69 as a novel Rab2 effector and its role in regulating the early transport of insulin secretory granule proteins PMID: 18187231

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Subcellular Location

Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Note=Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules.

Tissue Specificity

Expressed abundantly in pancreas, heart and brain with low levels of expression in lung, kidney, liver and thyroid.

Database Links

HGNC: 5343

OMIM: 147625

KEGG: hsa:3382

STRING: 9606.ENSP00000379908

UniGene: Hs.487561

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Service

Phage Display Service

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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