ICA1 Antibody

Code CSB-PA12109A0Rb
Size US$166
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Image
  • Western blot
    All lanes: ICA1 antibody at 2µg/ml + A549 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 55, 58 kDa
    Observed band size: 55 kDa

  • Western Blot
    Positive WB detected in: Mouse brain tissue
    All lanes: ICA1 antibody at 4µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 55, 58 kDa
    Observed band size: 55 kDa

  • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA12109A0Rb at dilution of 1:50

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ICA1 Polyclonal antibody
Uniprot No.
Target Names
ICA1
Alternative Names
69 kDa islet cell autoantigen antibody; Diabetes mellitus type I autoantigen antibody; ICA 1 antibody; Ica1 antibody; ICA69 antibody; ICA69_HUMAN antibody; ICAp69 antibody; Islet cell autoantigen 1 (69kD) antibody; Islet cell autoantigen 1 69kDa antibody; Islet cell autoantigen 1 antibody; Islet cell autoantigen 1 isoform antibody; Islet cell autoantigen p69 antibody; OTTHUMP00000200933 antibody; OTTHUMP00000200934 antibody; OTTHUMP00000200941 antibody; OTTHUMP00000200993 antibody; p69 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Islet cell autoantigen 1 protein (1-268AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ICA1 Antibody (Product code: CSB-PA12109A0Rb) is Non-conjugated. For ICA1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA12109B0Rb ICA1 Antibody, HRP conjugated ELISA
FITC CSB-PA12109C0Rb ICA1 Antibody, FITC conjugated
Biotin CSB-PA12109D0Rb ICA1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May play a role in neurotransmitter secretion.
Gene References into Functions
  1. C-terminal domain of ICA69 interacts with PICK1 and acts on trafficking of PICK1-PKCalpha complex and cerebellar plasticity. PMID: 24358315
  2. Novel association was found between intraocular pressure and a common variant at 7p21 near to GLCCI1 and ICA1. PMID: 23836780
  3. polymorphisms within the NOD Ica1 core promoter may determine AIRE-mediated down-regulation of ICA69 expression in medullary thymic epithelial cells. PMID: 22447927
  4. The exon A promoter exhibits greater activity in islet cells, whereas the exon B promoter more efficiently activates transcription in neuronal cells. PMID: 12409289
  5. ICA69 as a novel Rab2 effector and its role in regulating the early transport of insulin secretory granule proteins PMID: 18187231

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Subcellular Location
Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Note=Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules.
Tissue Specificity
Expressed abundantly in pancreas, heart and brain with low levels of expression in lung, kidney, liver and thyroid.
Database Links

HGNC: 5343

OMIM: 147625

KEGG: hsa:3382

STRING: 9606.ENSP00000379908

UniGene: Hs.487561

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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