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| Code | CSB-PA011580LA01BO |
| Size | US$299 How to order? |
| The Latest Promotion |  |
| Have Questions? | Leave a Message or Start an on-line Chat |
| Full Product Name | Rabbit anti-Bos taurus (Bovine) IL10 Polyclonal antibody |
| Uniprot No. | P43480 |
| Target Names | IL10 |
| Alternative Names | IL10Interleukin-10 antibody; IL-10 antibody; Cytokine synthesis inhibitory factor antibody; CSIF antibody |
| Raised in | Rabbit |
| Species Reactivity | Bovine |
| Immunogen | Recombinant Bovine Interleukin-10 protein (19-178AA) |
| Immunogen Species | Bos taurus (Bovine) |
| Conjugate | Non-conjugated The IL10 Antibody (Product code: CSB-PA011580LA01BO) is Non-conjugated. For IL10 Antibody with conjugates, please check the following table. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification Method | >95%, Protein G purified |
| Concentration | It differs from different batches. Please contact us to confirm it. |
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Form | Liquid |
| Tested Applications | ELISA |
| Protocols | ELISA Protocol |
| Troubleshooting and FAQs | Antibody FAQs |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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| Function |
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling.
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| Gene References into Functions |
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| Subcellular Location | Secreted. |
| Protein Families | IL-10 family |
| Database Links |
KEGG: bta:281246 STRING: 9913.ENSBTAP00000008793 UniGene: Bt.4723 |
