ITCH Antibody

Datasheet
Code CSB-PA060278
Size US$167
Uniprot No. Q96J02
Protocols Western Blotting(WB) Protocol
ELISA Protocol
Immunogen Synthesized peptide derived from Human AIP4 around the non-phosphorylation site of Y420.
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications WB,ELISA;WB:1/500-1/2000.ELISA:1/40000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias ITCH; E3 ubiquitin-protein ligase Itchy homolog; Itch; Atrophin-1-interacting protein 4; AIP4; NFE2-associated polypeptide 1; NAPP1
Immunogen Species Homo sapiens (Human)
Target Names ITCH
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates
Involvement in disease Autoimmune disease, multisystem, with facial dysmorphism (ADMFD)
Subcellular Location Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cytoplasm, Nucleus, Early endosome membrane, Peripheral membrane protein, Cytoplasmic side, Endosome membrane, Peripheral membrane protein, Cytoplasmic side
Tissue Specificity Widely expressed.
Database Links

HGNC: 13890

OMIM: 606409

KEGG: hsa:83737

STRING: 9606.ENSP00000363998

UniGene: Hs.632272

Pathway TNF signaling pathway
Ubiquitin mediated proteolysis
Endocytosis

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