Ly6e Antibody

Code CSB-PA717533LA01MO
Size US$166
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  • Western blot
    All lanes: Ly6e antibody at 8µg/ml + Hela whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 14 kDa
    Observed band size: 14 kDa

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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Ly6e Polyclonal antibody
Uniprot No.
Target Names
Ly6e
Alternative Names
Ly6e antibody; Ly67 antibody; Sca-2 antibody; Tsa-1Lymphocyte antigen 6E antibody; Ly-6E antibody; Stem cell antigen 2 antibody; Thymic shared antigen 1 antibody; TSA-1 antibody
Raised in
Rabbit
Species Reactivity
Mouse, Human
Immunogen
Recombinant Mouse Lymphocyte antigen 6E protein (21-102AA)
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated

The Ly6e Antibody (Product code: CSB-PA717533LA01MO) is Non-conjugated. For Ly6e Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA717533LB01MO Ly6e Antibody, HRP conjugated ELISA
FITC CSB-PA717533LC01MO Ly6e Antibody, FITC conjugated
Biotin CSB-PA717533LD01MO Ly6e Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of murine coronavirus, mouse hepatitis virus, by interfering with spike protein-mediated membrane fusion. Plays also an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response.
Gene References into Functions
  1. Knocking down Ly6e greatly reduced SynA-induced cell fusion, thus suggesting that Ly6e is the sole receptor for SynA in vivo. PMID: 28679758
  2. Sca-2 -- a signal transducer situated at the nexus of surface molecules regulating death receptor-mediated apoptosis in hepatoma PMID: 15170814
Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Specificity
Ubiquitously expressed in mouse adult tissues with maximal expression in the lung and the salivary gland. Expression is strikingly lower in the fetal tissues except for the placenta. Present in thymus where its expression is observed in immature thymocyte
Database Links

KEGG: mmu:17069

STRING: 10090.ENSMUSP00000056703

UniGene: Mm.788

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