Ly6e Antibody

Datasheet

Code	CSB-PA717533LA01MO
Size	US$166
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Image	Western blot All lanes: Ly6e antibody at 8µg/ml + Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 14 kDa Observed band size: 14 kDa
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Target Background

Product Details

Full Product Name

Rabbit anti-Mus musculus (Mouse) Ly6e Polyclonal antibody

Uniprot No.

Q64253

Target Names

Ly6e

Alternative Names

Ly6e antibody; Ly67 antibody; Sca-2 antibody; Tsa-1Lymphocyte antigen 6E antibody; Ly-6E antibody; Stem cell antigen 2 antibody; Thymic shared antigen 1 antibody; TSA-1 antibody

Raised in

Rabbit

Species Reactivity

Mouse, Human

Immunogen

Recombinant Mouse Lymphocyte antigen 6E protein (21-102AA)

Immunogen Species

Mus musculus (Mouse)

Conjugate

Non-conjugated

The Ly6e Antibody (Product code: CSB-PA717533LA01MO) is Non-conjugated. For Ly6e Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA717533LB01MO	Ly6e Antibody, HRP conjugated	ELISA
FITC	CSB-PA717533LC01MO	Ly6e Antibody, FITC conjugated
Biotin	CSB-PA717533LD01MO	Ly6e Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of murine coronavirus, mouse hepatitis virus, by interfering with spike protein-mediated membrane fusion. Plays also an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response.

Gene References into Functions

Knocking down Ly6e greatly reduced SynA-induced cell fusion, thus suggesting that Ly6e is the sole receptor for SynA in vivo. PMID: 28679758
Sca-2 -- a signal transducer situated at the nexus of surface molecules regulating death receptor-mediated apoptosis in hepatoma PMID: 15170814

Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Tissue Specificity

Ubiquitously expressed in mouse adult tissues with maximal expression in the lung and the salivary gland. Expression is strikingly lower in the fetal tissues except for the placenta. Present in thymus where its expression is observed in immature thymocyte

Database Links

KEGG: mmu:17069

STRING: 10090.ENSMUSP00000056703

UniGene: Mm.788

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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