MAPT (Ab-205) Antibody

Datasheet
Code CSB-PA247791
Product Type Polyclonal Antibody
Former Code(s) CSB-PA228796
Size US$297
Uniprot No. P10636
Image
  • Western blot analysis of extracts from Mouse Brain tissue using Tau(Ab-205) Antibody.
Immunogen Peptide sequence around aa.203~207 (P-G-T-P-G) derived from Human Tau.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Specificity The antibody detects endogenous level of total Tau protein.
Tested Applications ELISA,WB;WB:1:500-1:1000
Relevance

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

del C Alonso A, et al. (2004) J Biol Chem; 279(33): 34873-81
Li G, Yin H, Kuret J (2004) J Biol Chem; 279(16): 15938-45
Giasson BI, et al. (2002) Biochemistry; 41(51): 15376-87
Liu F, et al. (2002) FEBS Lett; 530(1-3): 209
Taniguchi T, et al. (2001) J Biol Chem; 276(13): 10025-31

Form Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality Polyclonal
Alias Neurofibrillary tangle protein; Paired helical filament-tau; MAPT; MTAPT; MTBT1
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Target Names MAPT
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Involvement in disease Frontotemporal dementia (FTD); Pick disease of the brain (PIDB); Progressive supranuclear palsy 1 (PSNP1); Parkinson-dementia syndrome (PARDE)
Subcellular Location Cytoplasm, cytosol, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cytoplasm, cytoskeleton, Cell projection, axon
Tissue Specificity Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
Database Links

HGNC: 6893

OMIM: 157140

KEGG: hsa:4137

STRING: 9606.ENSP00000340820

UniGene: Hs.101174

Pathway MAPK signaling pathway

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