Product Details

Uniprot No.

Target Names

Alternative Names

Cervical cancer proto oncogene 5 antibody; DNA polymerase alpha holoenzyme associated P1 antibody; DNA polymerase alpha holoenzyme associated protein P1 antibody; DNA polymerase alpha holoenzyme-associated protein P1 antibody; DNA replication factor MCM3 antibody; DNA replication licensing factor mcm3 antibody; HCC 5 antibody; HCC5 antibody; hRlf beta subunit antibody; Human cervical cancer proto oncogene 5 antibody; MCM 3 antibody; mcm3 antibody; MCM3 minichromosome maintenance deficient 3 antibody; MCM3_HUMAN antibody; MGC1157 antibody; Minichromosome maintenance complex component 3 antibody; Minichromosome maintenance deficient 3 antibody; Minichromosome maintenance protein 3 antibody; P1 h antibody; P1 MCM3 antibody; P1 Protein antibody; P1-MCM3 antibody; P1.h antibody; p102 antibody; P102 protein antibody; Replication licensing factor beta subunit antibody; RLF beta subunit antibody; RLF subunit beta antibody; RLFB antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human MCM3

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Related Products

Target Background

Function

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.

Gene References into Functions

this study shows that MCM3 is a novel proliferation marker in oral squamous cell carcinoma PMID: 27258565
High MCM3 expression is associated with bone metastasis and advanced human prostate cancer. PMID: 28424404
reveal the Minichromosome Maintenance Complex to be a critical and directly regulated node within the miR-183 signaling network in MYCN-amplified neuroblastoma cells. Randomly selected MCMs 3 and 5 were experimentally confirmed as direct targets of miR-183. PMID: 27239679
The results of our preliminary study emphasize the need for future research on MCM-3 as a sensitive proliferation marker, providing an alternative to Ki-67, in cases of various major salivary gland epithelial tumors in children and adolescents. PMID: 28547962
These data establish new functions for KEAP1 within the nucleus and identify MCM3 as a novel substrate of the KEAP1-CUL3-RBX1 E3 ligase. PMID: 27621311
The aim of this study is to analyze the immunoexpression of Ki67, p53, MCM3 and PCNA markers in epithelial remnants of dental follicles of impacted teeth and to identify a possible correlation between the immunoexpression of these markers in dentigerous cysts and keratocystic odontogenic tumors. PMID: 27516012
High MCM-3 expression correlated with Cutaneous T-cell Lymphomas. PMID: 26504025
normal DNA replication and replication checkpoint activation is regulated through the novel phosphorylation of MCM3 by Chk1 PMID: 25809478
The relatively lower MCM3 protein expression in FVPTC. PMID: 23821456
Expression of KB cell MCM3 was not affected by doxorubicin. PMID: 24344040
present study aimed to investigate the relationship between expression of minichromosome maintenance proteins (MCM-3, MCM-7), metallothioneins (MT-I/II, MT-III), and Ki-67 in 103 ovarian cancer cases, mostly of the serous histological type PMID: 24324072
High MCM3 expression is associated with mucoepidermoid carcinomas and adenoid cystic carcinomas in salivary gland tumors. PMID: 23886132
Relatively lower MCM3 protein expression in follicular variant of papillary thyroid carcinoma comparing to classical type could be due to a different tumorigenic pathway favored in this type of tissue. PMID: 23821456
These findings provide validation of the utility of MCM3 expression as an independent biomarker for prognostication of patients with primary melanoma PMID: 22805320
excess of MCM3 up-regulates the phosphorylation of CHK1 Ser-345 and CDK2 Thr-14. PMID: 21965652
MCM3 gene expression is decreased in follicular variant of papillary thyroid carcinoma, contrary to expectation. PMID: 21509594
Using U373MG cells we found that HCMV IE86 protein was bound to Mcm3, but did not inhibit the cellular DNA synthesis. PMID: 20545442
MCM3 may be a more reliable proliferation marker than Ki-67 in accessing the growth of tumor and evaluating tumor aggressiveness of papillary thyroid carcinoma. PMID: 19818763
The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with this protein PMID: 12226073
Elevated MCM3 protein expression is associated with neoplasms PMID: 15623617
MCM3 is overexpressed in human astrocytic tumors and elicits a cancer-restricted humoral immune response in some patients with brain neoplasms PMID: 15671553
ORC1 and Mcm3 proteins are required for DNA replication in protein extracts from human cells PMID: 16537544
analysis of carboxyl-terminal MCM3 phosphorylation sites and their motifs PMID: 17244605
These data reveal that CDK-dependent MCM3 phosphorylation contributes to the regulated formation of the MCM2-7 complex. PMID: 18524952