Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MOV10 Polyclonal antibody

Uniprot No.

Q9HCE1

Target Names

MOV10

Alternative Names

MOV10 antibody; KIAA1631 antibody; Helicase MOV-10 antibody; EC 3.6.4.13 antibody; Armitage homolog antibody; Moloney leukemia virus 10 protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Putative helicase MOV-10 protein (601-900AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs. Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2. Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1. Facilitates LINE-1 uridylation by TUT4 and TUT7. Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol. May function as a messenger ribonucleoprotein (mRNP) clearance factor. Exhibits antiviral activity against dengue virus (DENV).; (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.

Gene References into Functions

Through interference with the ubiquitin-proteasome system, MOV10 enhances the level of apolipoprotein-B-mRNA-editing enzyme catalytic polypeptide-like 3G in HIV-1-infected cells and virions, and synergistically inhibits the replication and infectivity of HIV-1. PMID: 29258557
these results establish MOV10, an evolutionary conserved protein involved in RNA silencing, as an antiviral gene against RNA viruses that uses an retinoic acid-inducible gene I-like receptor-independent pathway to enhance IFN response PMID: 27016603
IRAV is an RNA binding protein and localizes to cytoplasmic processing bodies (P bodies) in uninfected cells, where it interacts with the MOV10 RISC complex RNA helicase, suggesting a role for IRAV in the processing of viral RNA. PMID: 27974568
MOV10 is a highly conserved cellular protein belonging to SF1 helicase family that plays critical roles in EV71 infection PMID: 27666477
MOV10 acts as an anti-influenza virus factor through specifically inhibiting the nuclear transportation of nucleoprotein and subsequently inhibiting the function of the viral ribonucleoprotein complex PMID: 26842467
The DEAG-box of huamn MOV10 was required for the enhancement of Rev/RRE-dependent nuclear export. PMID: 26379090
The endogenous Mov10 could promote hepatitis B virus replication in vitro. PMID: 25533532
A dual function for MOV10 in regulating translation: it facilitates microRNA-mediated translation of some RNAs, but it also increases expression of other RNAs by preventing AGO2 function. PMID: 25464849
Results show that MOV10 predominantly binds to 3' UTRs upstream of regions predicted to form local secondary structures and provide evidence that MOV10 helicase mutants are impaired in their ability to translocate 5' to 3' on their mRNA targets. PMID: 24726324
Association of the SNP rs2932538 in MOV10 and SNP rs4373814 in CACNB2 with an increased risk of hypertension in a Chinese Han population. PMID: 24338417
MOV10 contributes to the cellular control of long interspersed element 1 replication. PMID: 23754279
Authors conclude that HIV-1 virion incorporation and the antiviral activities of Mov10 and APOBEC3G do not require their localization to P bodies. PMID: 23926332
Depletion of endogenous MOV10 significantly enhances the retrotransposition of endogenous retroelements. PMID: 22727223
APOBEC3G inhibits microRNA-mediated repression of translation by interfering with the interaction between Argonaute-2 and MOV10 PMID: 22791714
identified two critical MOV10 packaging determinants and eight other critical residues for anti-HIV-1 activity PMID: 22105071
Results suggest that Mov10 could be required during the lentiviral lifecycle and that its perturbation disrupts generation of infectious viral particles. PMID: 20140200
MOV10, co-purifies and interacts with components of Polycomb-repressive complex 1 from human cells. Knockdown of MOV10 in human fibroblasts leads to the upregulation of the INK4a. PMID: 20543829
The identification of capped small RNAs and the involvement of MOV10 in hepatitis delta virus replication further suggest a conserved mechanism related to RNA-directed transcription in lower eukaryotes. PMID: 18552826
These data suggest that MOV10 is involved in the progression of telomerase-catalyzing reaction via the interaction of telomerase protein and telomere DNA. PMID: 19665004
Mov10 coimmunoprecipitates with human Ago1 and Ago2 and also colocalizes with them in cytoplasmic P-bodies. PMID: 16289642