MOV10 Antibody

1. Through interference with the ubiquitin-proteasome system, MOV10 enhances the level of apolipoprotein-B-mRNA-editing enzyme catalytic polypeptide-like 3G in HIV-1-infected cells and virions, and synergistically inhibits the replication and infectivity of HIV-1. PMID: 29258557
2. these results establish MOV10, an evolutionary conserved protein involved in RNA silencing, as an antiviral gene against RNA viruses that uses an retinoic acid-inducible gene I-like receptor-independent pathway to enhance IFN response PMID: 27016603
3. IRAV is an RNA binding protein and localizes to cytoplasmic processing bodies (P bodies) in uninfected cells, where it interacts with the MOV10 RISC complex RNA helicase, suggesting a role for IRAV in the processing of viral RNA. PMID: 27974568
4. MOV10 is a highly conserved cellular protein belonging to SF1 helicase family that plays critical roles in EV71 infection PMID: 27666477
5. MOV10 acts as an anti-influenza virus factor through specifically inhibiting the nuclear transportation of nucleoprotein and subsequently inhibiting the function of the viral ribonucleoprotein complex PMID: 26842467
6. The DEAG-box of huamn MOV10 was required for the enhancement of Rev/RRE-dependent nuclear export. PMID: 26379090
7. The endogenous Mov10 could promote hepatitis B virus replication in vitro. PMID: 25533532
8. A dual function for MOV10 in regulating translation: it facilitates microRNA-mediated translation of some RNAs, but it also increases expression of other RNAs by preventing AGO2 function. PMID: 25464849
9. Results show that MOV10 predominantly binds to 3' UTRs upstream of regions predicted to form local secondary structures and provide evidence that MOV10 helicase mutants are impaired in their ability to translocate 5' to 3' on their mRNA targets. PMID: 24726324
10. Association of the SNP rs2932538 in MOV10 and SNP rs4373814 in CACNB2 with an increased risk of hypertension in a Chinese Han population. PMID: 24338417
11. MOV10 contributes to the cellular control of long interspersed element 1 replication. PMID: 23754279
12. Authors conclude that HIV-1 virion incorporation and the antiviral activities of Mov10 and APOBEC3G do not require their localization to P bodies. PMID: 23926332
13. Depletion of endogenous MOV10 significantly enhances the retrotransposition of endogenous retroelements. PMID: 22727223
14. APOBEC3G inhibits microRNA-mediated repression of translation by interfering with the interaction between Argonaute-2 and MOV10 PMID: 22791714
15. identified two critical MOV10 packaging determinants and eight other critical residues for anti-HIV-1 activity PMID: 22105071
16. Results suggest that Mov10 could be required during the lentiviral lifecycle and that its perturbation disrupts generation of infectious viral particles. PMID: 20140200
17. MOV10, co-purifies and interacts with components of Polycomb-repressive complex 1 from human cells. Knockdown of MOV10 in human fibroblasts leads to the upregulation of the INK4a. PMID: 20543829
18. The identification of capped small RNAs and the involvement of MOV10 in hepatitis delta virus replication further suggest a conserved mechanism related to RNA-directed transcription in lower eukaryotes. PMID: 18552826
19. These data suggest that MOV10 is involved in the progression of telomerase-catalyzing reaction via the interaction of telomerase protein and telomere DNA. PMID: 19665004
20. Mov10 coimmunoprecipitates with human Ago1 and Ago2 and also colocalizes with them in cytoplasmic P-bodies. PMID: 16289642

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HGNC: 7200

OMIM: 610742

KEGG: hsa:4343

STRING: 9606.ENSP00000350028

UniGene: Hs.514941