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| Code | CSB-PA013481YA01RA |
| See More Details |  |
| Size | US$299 |
| Uniprot No. | P19332 |
| Protocols | ELISA Protocol |
| Immunogen | Recombinant Rat Microtubule-associated protein tau protein (2-752AA) |
| Raised in | Rabbit |
| Species Reactivity | Rat |
| Tested Applications | ELISA |
| Relevance | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. |
| Form | Liquid |
| Conjugate | Non-conjugated |
| Storage Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method | >95%, Protein G purified |
| Isotype | IgG |
| Clonality | Polyclonal |
| Alias | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau), Mapt, Mtapt Tau |
| Immunogen Species | Rattus norvegicus (Rat) |
| Research Area | Neuroscience |
| Target Names | Mapt |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
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| Function | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. |
| Subcellular Location | Cytoplasm, cytosol, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cytoplasm, cytoskeleton, Cell projection, axon |
| Tissue Specificity | Expressed in neurons. The larger forms (isoform tau-A and isoform tau-B) are preferentially expressed in the peripheral nervous system while the other are expressed in the central nervous system. Low amounts of the larger forms are also found in limited a |
| Database Links |
STRING: 10116.ENSRNOP00000006856 UniGene: Rn.2455 |
| Pathway | MAPK signaling pathway |
Mapt Antibodies for Rattus norvegicus (Rat)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA013481YD01RA | Mapt Antibody, Biotin conjugated | Rat | ELISA |
| CSB-PA013481YC01RA | Mapt Antibody, FITC conjugated | Rat | ELISA |
| CSB-PA013481YB01RA | Mapt Antibody, HRP conjugated | Rat | ELISA |
| CSB-PA945056 | Mapt Antibody | Human,Mouse,Rat | ELISA,WB |
Mapt Proteins for Rattus norvegicus (Rat)
| Code | Product Name | Source |
|---|---|---|
| CSB-EP013481RA | Recombinant rat Microtubule-associated protein tau | E.coli |
| CSB-YP013481RA | Recombinant Rat Microtubule-associated protein tau(Mapt) | Yeast |
| CSB-BP013481RA CSB-MP013481RA |
Recombinant Rat Microtubule-associated protein tau(Mapt) | Baculovirus Mammalian cell |
Mapt ELISA Kit for Rattus norvegicus (Rat)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E13729r | Rat Tau Proteins ELISA kit | serum, plasma, cerebrospinal fluid (CSF) | 15.6 pg/mL |
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