NECTIN2 Antibody

Code CSB-PA835690LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: HepG2 whole cell lysate, A549 whole cell lysate, Hela whole cell lysate
    All lanes: NECTIN2 antibody at 3μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 58, 52 kDa
    Observed band size: 58 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NECTIN2 Polyclonal antibody
Uniprot No.
Target Names
NECTIN2
Alternative Names
CD 112 antibody; CD112 antibody; CD112 antigen antibody; Herpes virus entry mediator B antibody; Herpes virus entry protein B antibody; Herpesvirus entry mediator B antibody; Herpesvirus entry protein B antibody; Hve B antibody; HveB antibody; Nectin-2 antibody; Nectin2 antibody; Poliovirus receptor like 2 antibody; Poliovirus receptor related 2 (herpesvirus entry mediator B) antibody; Poliovirus receptor related 2 antibody; Poliovirus receptor related protein 2 antibody; Poliovirus receptor-related protein 2 antibody; PRR 2 antibody; PRR2 antibody; PVRL 2 antibody; PVRL2 antibody; PVRL2_HUMAN antibody; PVRR 2 antibody; PVRR2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Nectin-2 protein (32-360AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The NECTIN2 Antibody (Product code: CSB-PA835690LA01HU) is Non-conjugated. For NECTIN2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA835690LB01HU NECTIN2 Antibody, HRP conjugated ELISA
FITC CSB-PA835690LC01HU NECTIN2 Antibody, FITC conjugated
Biotin CSB-PA835690LD01HU NECTIN2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein.; (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).
Gene References into Functions
  1. Nectin-2 mutation in men with severe teratospermia PMID: 28689229
  2. In the infection with 3 MLD50 (50 % mouse lethal dose), effective resistance was not observed in transgenic mice expressing nectin-2Ig. PMID: 28671524
  3. Our data provide important structural and biochemical determinants responsible for the recognition of nectin-2 by TIGIT. PMID: 27978489
  4. Chromosomal breakpoints involved the PVRR2 gene in 19q31 is associated with Diffuse Large B-Cell Lymphomas. PMID: 27356265
  5. energetic basis for the TIGIT/nectin-2 interaction and revealed that an "aromatic key" of nectin-2 is critical for this interaction, whereas variations in the lock were tolerated. PMID: 28515320
  6. PVRL2 is a plasma cholesterol-responsive gene acting at endothelial sites of vascular inflammation to regulate transendothelial migration of leukocytes. PMID: 28062492
  7. Serum levels of nectin-2 may have diagnostic roles for colorectal cancer patients. PMID: 26184725
  8. Soluble form of nectin-2 is required for exerting the resistance against HSV-2 infection. PMID: 26982466
  9. PVRL2, TOMM40 and APOE might be associated with human longevity. PMID: 24924924
  10. Nectin-3 trans-interacts with Nectin-2 to promote lymphocyte and monocyte extravasation. PMID: 24116228
  11. Chorionic gonadotropin induces vascular endothelial growth factor (VEGFA)-dependent downregulation of nectin 2, which increases the endothelial permeability in the coculture system. PMID: 23465821
  12. Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion. PMID: 22927415
  13. a possible etiologic role of PRR2 in nonsyndromic cleft lip with or without cleft palate PMID: 20662561
  14. The CD112 is highly expressed in colon carcinoma tissues and cell lines. PMID: 20617580
  15. The authors now show that human cytomegalovirus targets CD112 for proteasome-mediated degradation by 48 h post-infection, thus removing both activating ligands for DNAM-1 from the cell surface during productive infection. PMID: 20410314
  16. differences in the N termini of herpes simplex virus type 1 and 2 gDs that influence functional interactions with the human entry receptor Nectin-2 PMID: 12915581
  17. There is an allelic association of sequence variation in PVRL2 and the severity of multiple sclerosis. PMID: 16738668
  18. CD226/CD112 (DNAM-1/Nectin-2) mast cell stimulation has a role in the allergic process PMID: 16831868
  19. identified PVRL2 as a new recurrent partner gene of the TRA@ locus in peripheral T-cell lymphoma PMID: 17696193
  20. Crystallization and preliminary X-ray analysis of the V domain of human nectin-2 are reported. PMID: 19478445
  21. Regions of nectin-2 protein important for herpesvirus entry activity and homotypic nectin-nectin interactions are overlapping but not identical. PMID: 12438620

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
Nectin family
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 9707

OMIM: 600798

KEGG: hsa:5819

STRING: 9606.ENSP00000252483

UniGene: Hs.655455

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