PSMA1 Antibody

Code CSB-PA018865LA01HU
Size US$299 How to order?
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  • Western Blot
    Positive WB detected in: Hela whole cell lysate, PC-3 whole cell lysate, K562 whole cell lysate
    All lanes: PSMA1 antibody at 3.4μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 30, 31 kDa
    Observed band size: 30 kDa

  • Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA018865LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA018865LA01HU at dilution of 1:100

  • Immunofluorescent analysis of PC-3 cells using CSB-PA018865LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Immunoprecipitating PSMA1 in K562 whole cell lysate
    Lane 1: Rabbit control IgG (1μg) instead of CSB-PA018865LA01HU in K562 whole cell lysate. For western blotting, a HRP-conjugated light chain specific antibody was used as the secondary antibody (1/50000)
    Lane 2: CSB-PA018865LA01HU (8μg) + K562 whole cell lysate (500μg)
    Lane 3: K562 whole cell lysate (10μg)

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PSMA1 Polyclonal antibody
Uniprot No. P25786
Target Names PSMA1
Alternative Names 30 kDa prosomal protein antibody; HC 2 antibody; HC2 antibody; Macropain subunit C2 antibody; Macropain subunit nu antibody; MGC14542 antibody; MGC14575 antibody; MGC14751 antibody; MGC1667 antibody; MGC21459 antibody; MGC22853 antibody; MGC23915 antibody; Multicatalytic endopeptidase complex subunit C2 antibody; NU antibody; PROS 30 antibody; PROS-30 antibody; PROS30 antibody; Proteasome (prosome macropain) subunit alpha type 1 antibody; Proteasome alpha 1 subunit antibody; Proteasome component C2 antibody; Proteasome nu chain antibody; Proteasome subunit alpha type 1 antibody; Proteasome subunit alpha type I antibody; Proteasome subunit alpha type-1 antibody; Proteasome subunit nu antibody; Protein P30 33K antibody; PSA1_HUMAN antibody; PSC 2 antibody; PSC2 antibody; PSMA 1 antibody; psmA1 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Proteasome subunit alpha type-1 protein (163-263AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated

The PSMA1 Antibody (Product code: CSB-PA018865LA01HU) is Non-conjugated. For PSMA1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA018865LB01HU PSMA1 Antibody, HRP conjugated ELISA
FITC CSB-PA018865LC01HU PSMA1 Antibody, FITC conjugated
Biotin CSB-PA018865LD01HU PSMA1 Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB, IHC, IF, IP
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
IF 1:50-1:200
IP 1:200-1:2000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Immunoprecipitation (IP) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Gene References into Functions
  1. In thyroid hemiagenesis, genomic examinations revealed the presence of four recurrent defects (three deletions and one duplication) affecting highly conservative proteasome genes PSMA1, PSMA3, and PSMD3. PMID: 28390009
  2. Data indicate that RNA interference screens identified PSMA1, a component of the 20S proteasome as target of non-small cell lung cancer (NSCLC) cytotoxicity. PMID: 24040035
  3. LC/MS/MS analysis revealed that the C-terminal 16 residues of sperm alpha6 subunit are processed. PMID: 21703233
Subcellular Location Cytoplasm. Nucleus.
Protein Families Peptidase T1A family
Database Links

HGNC: 9530

OMIM: 602854

KEGG: hsa:5682

STRING: 9606.ENSP00000414359

UniGene: Hs.102798

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