PTGS2 Antibody, HRP conjugated

Code CSB-PA018986LB01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PTGS2 Polyclonal antibody
Uniprot No. P35354
Target Names PTGS2
Alternative Names COX 2 antibody; COX-2 antibody; COX2 antibody; Cyclooxygenase 2 antibody; Cyclooxygenase 2b antibody; Cyclooxygenase antibody; Cyclooxygenase-2 antibody; Cyclooxygenase2 antibody; EC 1.14.99.1 antibody; fj02a10 antibody; Glucocorticoid-regulated inflammatory cyclooxygenase antibody; Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase antibody; GRIPGHS antibody; hCox 2 antibody; Macrophage activation-associated marker protein P71/73 antibody; OTTHUMP00000033524 antibody; PES-2 antibody; PGG/HS antibody; PGH synthase 2 antibody; PGH2_HUMAN antibody; PGHS 2 antibody; PGHS-2 antibody; PGHS2 antibody; PHS 2 antibody; PHS II antibody; PHS2 antibody; Prostaglandin endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) antibody; Prostaglandin endoperoxide synthase 2 antibody; Prostaglandin G/H synthase 2 antibody; Prostaglandin G/H synthase 2 precursor antibody; Prostaglandin G/H synthase and cyclooxygenase antibody; Prostaglandin G/H synthase antibody; Prostaglandin H2 synthase 2 antibody; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) antibody; Prostaglandin-endoperoxide synthase 2 antibody; PTGS2 antibody; ptgs2a antibody; TIS10 antibody; TIS10 protein antibody; unp1239 antibody; wu:fj02a10 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Prostaglandin G/H synthase 2 protein (18-268AA)
Immunogen Species Homo sapiens (Human)
Conjugate HRP
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
Gene References into Functions
  1. SND1 may act as a potential biomarker of the therapeutic strategies utilizing COX2 inhibitors. PMID: 30365124
  2. Authors showed that mRNA and protein levels of COX2 and HER2 were upregulated in CRC compared with the adjacent tissues. COX2 protein levels and nuclear COX2 expression were correlated with a poor prognosis of CRC patients. COX2 expression was positively associated with HER2 expression. PMID: 29873317
  3. PTGS2 polymorphisms were associated with advanced liver fibrosis in patients with HCV mono-Infection and HCV/HIV Co-Infection. PMID: 30139224
  4. An unrecognized cellular interaction between follicular dendritic cells and B cells leading to COX-2 expression during immune inflammatory responses. PMID: 29241029
  5. Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in Alzheimer's disease patients and in a transgenic mouse model. PMID: 29662056
  6. miR-137 suppresses the proliferation and invasion of retinoblastoma cells by targeting COX-2/PGE2 signaling pathway. PMID: 29945115
  7. Dual governing of YAP and COX-2 may lead to the discovery of promising therapeutic strategies for HCC patients. PMID: 29505957
  8. COX-2 expression was positively associated with the recurrence and a poor prognosis of patients with nasopharyngeal carcinoma. PMID: 29956730
  9. COX-2 is an important factor for Dengue virus replication. PMID: 28317866
  10. Lysophosphatidylcholine induces COX-2-mediated IL-6 expression. NADPH oxidase/Reactive Oxygen Species is involved in Lysophosphatidylcholine-induced COX-2 expression. PMID: 30229288
  11. results support a critical role of ATF6alpha in the establishment and maintenance of cellular senescence in normal human fibroblasts via the up-regulation of a COX2/PGE2 intracrine pathway. PMID: 28803844
  12. High PTGS2 expression is associated with Breast Carcinoma. PMID: 30051683
  13. concluded that COX-2 gene rs5275 variant contributes to Nasopharyngeal carcinoma risk in a Chinese population PMID: 30087034
  14. COX2 and YAP1 signaling pathways are connected with each other to induce SOX2 expression, cancer stem cell enrichment, and acquired resistance to chemotherapy in urothelial carcinoma of the bladder. PMID: 29180467
  15. No significant association between COX-2 8473 T > C polymorphism and cancer risk was detected. PMID: 30143023
  16. The results revealed that TLR4 and COX-2 were upregulated in PCa tissues; silencing of TLR4 or COX-2 inhibited PCa cell proliferation, migration, and invasion. PMID: 30098292
  17. Results describe a novel role for cyclooxygenase-2 (COX-2) in mediating the TGFbeta effects on breast cancer stem cells (BCSC) properties and imply that targeting the COX-2 pathway may prove useful for the treatment of triple-negative breast cancer by eliminating BCSCs. PMID: 28054666
  18. the effects of miR-101 inhibition on tumor growth were suppressed by COX-2 inhibition. PMID: 29404887
  19. Low PTGS2 expression is associated with Invasive Breast Carcinoma. PMID: 28808873
  20. rs2243250 (IL4) and rs5275 (PTGS2) were found to be significantly associated with shorter renal cell cancer-specific survival (CSS). PMID: 28117391
  21. meta-analysis demonstrated that COX-2 rs5275 and rs689466 polymorphism significantly decrease the risk of lung cancer in Asians but not in Caucasians, indicating COX-2 could serve as a potential diagnostic marker for lung cancer PMID: 30170377
  22. meta-analysis of association between 765G/C polymorphism and periodontitis in Chinese population PMID: 29514641
  23. Through downregulation of COX-2 expression in SGC-7901 and MGC-803 cells. PMID: 29901169
  24. Patients with a high expression of COX-2 in baseline tumor biopsies had less response to treatment of pathology compared to patients with lower expression of COX-2 in baseline tumor biopsies. PMID: 29893307
  25. Studied the association between integrin subunit alpha 2 (GPIa) and prostaglandin-endoperoxide synthase 2 (COX-2) genetic polymorphisms in Chinese ishemic stroke patients with or without aspirin resistance. PMID: 28948649
  26. COX-2 was significantly associated with a lower 5-year disease-free survival (DFS) rate PMID: 29559247
  27. The polymorphism in the COX2 gene is associated with increased susceptibility to colorectal cancer, specially rectosigmoid tumors PMID: 29257846
  28. demonstrate the unregulated expression of ANXA1 and COX-2 in precursor lesions of esophageal and stomach cancers PMID: 29254791
  29. The cytotoxicity induced by EB1 gene knockdown was due to the activation and generation of reactive oxygen species by p38 mitogen-activated protein kinase..this signaling cascade, however not nuclear factor-kappaB-mediated signaling, induced the expression of cyclooxygenase-2, a key effector of apoptotic death. PMID: 29484424
  30. High COX2 expression is associated with Ras and BRAF mutations in Hepatocellular Carcinoma. PMID: 28188432
  31. High COX2 expression is associated with ovarian cancer cell migration and invasion. PMID: 28677781
  32. hypothesize that lower transcript levels of PTGS2 in cumulus cells may be involved in the impairment of oocyte quality, suggesting a possible mechanism involved in disease-related infertility PMID: 28734688
  33. Results suggest that a significant correlation exists in Japan between the COX-2 1195 G-carrier genotype and intestinal metaplasia in histological and endoscopic findings based on Kyoto classification in H. pylori-infected gastric mucosa. PMID: 28946145
  34. activated Ras, protumorigenic COX-2 and Notch1 have roles in in papillary mucinous neoplasm onset PMID: 27381829
  35. TGF-beta1 increased the COX-2 and PGE2 level of cultured pulp cells. The effect of TGF-beta1 on COX-2 protein expression was associated with ALK5/Smad2/3 and MEK/ERK pathways. PMID: 28779848
  36. Culinary herbs and spices prevent the growth of HCA-7 colorectal adenocarcinoma cancer cells and inhibit their COX-2 expression. PMID: 28934138
  37. medical use of COX inhibitors in glioblastoma treatment has been limited due to their well-documented vascular toxicity and inconsistent outcomes from recent human studies. Prostaglandin E2 (PGE2) has emerged as a principal mediator for COX-2 cascade-driven gliomagenesis PMID: 28718447
  38. COX2 inversely regulated Notch1 in gastric cancer and partially depended on the Notch1 signalling pathway in altering the expression of Snail. PMID: 28586004
  39. Based on the contribution maps from the three techniques, it can be concluded that both the benzenesulfonyl group and the central five-membered ring - having a high-electronegativity functional group or atom or having a substituent hydrogen bonding acceptor - contribute positively to the selective inhibition of COX-2 PMID: 27145042
  40. Findings demonstrate that COX-2 and p-Akt1 play an important combined role during melanoma progression and are associated with highly metastatic tumors and survival rates in patients with MM. PMID: 28604419
  41. Results suggest that higher COX-2 expression may be a negative prognostic factor in conjunctival melanoma. Further studies can address the potential use of anti-COX-2 drugs as adjuvant therapy of this disease. PMID: 29297092
  42. activation of ERK1/2 signaling was required for hCG-induced up-regulation of SPRY2 expression. Further, SPRY2 knockdown attenuated the AREG-induced COX-2 expression and PGE2 production by inhibiting AREG-activated ERK1/2 signaling. PMID: 27539669
  43. COX-2 was elevated in glioma tissues and its expression was negatively correlated with the levels of miR-128. These findings may establish miR-128 as a new potential target for the treatment of patients with gliomas. PMID: 29524580
  44. Post-transcriptional regulation of COX-2 mRNAs translation by SGs indicates a role in IL-1beta-mediated catabolic response that could be therapeutically targeted in Osteoarthritis. PMID: 27271770
  45. Results show that in influenza A viruses (IAV)-infected cells, COX-2 expression is regulated. While the protein is induced at early time of infection, via recognition of IAV vRNA by RIG-I, COX-2 expression is reduced again during on-going replication due to destabilization of its mRNA by IAV-induced TTP. PMID: 27265729
  46. Our results highlight the role of COX-2 in constitutive IDO1 expression by human tumors and substantiate the use of COX-2 inhibitors to improve the efficacy of cancer immunotherapy, by reducing constitutive IDO1 expression, which contributes to the lack of T-cell infiltration in "cold" tumors, which fail to respond to immunotherapy PMID: 28765120
  47. Chinese population with GG genotype of COX-2 gene polymorphism rs689466 have higher risk to develope post-traumatic osteomyelitis. PMID: 28682162
  48. 4-Hydroxy-2-nonenal is a natural inducer of COX-2 in atherosclerosis. (Review) PMID: 28192229
  49. RhoA and COX-2 were upregulated in early gastric cancer tissues, which facilitated the proliferation and migration of gastric cancer cells. PMID: 28624843
  50. LXR gene expression was significantly increased in obese children with obstructive sleep apnea-hypopnea syndrome (OSAHS). The severity of OSAHS was positively correlated with COX-2 levels. PMID: 28676625

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Subcellular Location Microsome membrane, Peripheral membrane protein, Endoplasmic reticulum membrane, Peripheral membrane protein
Protein Families Prostaglandin G/H synthase family
Database Links

HGNC: 9605

OMIM: 600262

KEGG: hsa:5743

STRING: 9606.ENSP00000356438

UniGene: Hs.196384

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