Phospho-FAS (Y291) Antibody

Datasheet
Code CSB-PA009527
Former Code(s) CSB-PA011181
Size US$167
Uniprot No. P25445
Immunogen Synthesized peptide derived from Human FAS around the phosphorylation site of Y291.
Raised in Rabbit
Species Reactivity Human
Tested Applications IF,ELISA;IF:1/200-1/1000.ELISA:1/5000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias FAS; APT1; FAS1; TNFRSF6; Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; CD antigen CD95
Immunogen Species Homo sapiens (Human)
Protocols Immunofluorescence (IF) Protocol
ELISA Protocol
Target Names FAS
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Involvement in disease Autoimmune lymphoproliferative syndrome 1A (ALPS1A)
Subcellular Location Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Secreted, SUBCELLULAR LOCATION: Isoform 3: Secreted, SUBCELLULAR LOCATION: Isoform 4: Secreted, SUBCELLULAR LOCATION: Isoform 5: Secreted, SUBCELLULAR LOCATION: Isoform 6: Secreted
Tissue Specificity Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
Database Links

HGNC: 11920

OMIM: 134637

KEGG: hsa:355

STRING: 9606.ENSP00000347979

UniGene: Hs.244139

Pathway MAPK signaling pathway
p53 signaling pathway
TNF signaling pathway
Apoptosis
Necroptosis
Natural killer cell mediated cytotoxicity

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