FAS, tumor necrosis factor receptor superfamily member 6, alias APO-1, CD95, TNFRSF6, is a cell surface death receptor belonging to the tumor necrosis factor receptor superfamily. FAS is mainly expressed on the surface of cells of various tissues, and a small amount exists in plasma in a soluble form.
The mechanism of action of FAS is to form a death-inducing signaling complex (DISC) by binding to its ligand, FasL, which in turn activates the downstream caspase apoptosis cascade and causes apoptosis. FAS plays an important role in the immune system, especially in apoptosis, immune tolerance and anti-tumor immune response. Aberrant activation or inhibition of the FAS signaling pathway has been associated with a variety of diseases, including autoimmune diseases, certain types of cancer, and immunodeficiency diseases.
Recombinant Human Fatty acid synthase (FASN), partial (CSB-EP008435HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
FASN Recombinant Monoclonal Antibody (CSB-RA240595A0HU)
Validated Data
Immunofluorescence staining of Hela Cells with CSB-RA240595A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).
Overlay histogram showing A549 cells stained with CSB-RA240595A0HU (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1µg/1*106 cells) for 1 h at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1µg/1*106 cells) used under the same conditions. Acquisition of >10,000 events was performed.
Human Fatty acid synthase(FASN) ELISA kit (CSB-EL008435HU)
Validated Data
Code: CSB-EL008435HU
Size: 96T,5×96T,10×96T
Sensitivity: 0.39 ng/mL
Detection Range: 1.56 ng/mL-100 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following FAS reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
FAS Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA008435GA01HU | FASN Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA06354A0Rb | FAS Antibody | Human | ELISA, IHC, IF |
CSB-PA146193 | FAS Antibody | Human | ELISA,WB |
CSB-PA942791 | FAS Antibody | Human | ELISA,WB,IHC |
CSB-PA13179A0Rb | FASN Antibody | Human | ELISA, IHC, IF |
CSB-PA13179B0Rb | FASN Antibody, HRP conjugated | Human | ELISA |
CSB-PA001488 | FAS Antibody | Human | WB, IHC, ELISA |
CSB-PA002481 | FAS Antibody | Human | WB, IF, ELISA |
CSB-PA002507 | FASN Antibody | Human | WB, ELISA |
CSB-PA006041 | FAS Antibody | Human | WB, ELISA |
CSB-PA009527 | Phospho-FAS (Y291) Antibody | Human | IF, ELISA |
CSB-PA185779 | FAS Antibody | Human | ELISA,WB,IHC |
CSB-RA240595A0HU | FASN Recombinant Monoclonal Antibody | Human | ELISA, IF, FC |
CSB-RA252392A0HU | FAS Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
FAS Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP008433HU CSB-EP008433HU CSB-BP008433HU CSB-MP008433HU CSB-EP008433HU-B |
Recombinant Human Tumor necrosis factor receptor superfamily member 6 (FAS), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-YP008435HU CSB-BP008435HU CSB-MP008435HU CSB-EP008435HU-B |
Recombinant Human Fatty acid synthase (FASN), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP002311HU | Recombinant Human Tumor necrosis factor receptor superfamily member 6 protein (FAS), partial (Active) | E.coli |
CSB-EP008435HU | Recombinant Human Fatty acid synthase (FASN), partial | E.coli |
CSB-CF008433HU(A4) | Recombinant Human Tumor necrosis factor receptor superfamily member 6 (FAS) | in vitro E.coli expression system |
CSB-MP008433HU(A4) | Recombinant Human Tumor necrosis factor receptor superfamily member 6 (FAS)-VLPs | Mammalian cell |
FAS Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP737175RA CSB-EP737175RA CSB-BP737175RA CSB-MP737175RA CSB-EP737175RA-B |
Recombinant Rat Tumor necrosis factor receptor superfamily member 6 (Fas), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FAS Proteins for Macaca nemestrina (Pig-tailed macaque)
Code | Product Name | Source |
---|---|---|
CSB-YP857720MOX CSB-EP857720MOX CSB-BP857720MOX CSB-MP857720MOX CSB-EP857720MOX-B |
Recombinant Macaca nemestrina Tumor necrosis factor receptor superfamily member 6 (FAS), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FAS Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-YP859783MOW CSB-EP859783MOW CSB-BP859783MOW CSB-MP859783MOW CSB-EP859783MOW-B |
Recombinant Macaca mulatta Tumor necrosis factor receptor superfamily member 6 (FAS), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FAS Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
Code | Product Name | Source |
---|---|---|
CSB-YP861037DRI CSB-EP861037DRI CSB-BP861037DRI CSB-MP861037DRI CSB-EP861037DRI-B |
Recombinant Cercocebus atys Tumor necrosis factor receptor superfamily member 6 (FAS), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FAS Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Code | Product Name | Source |
---|---|---|
CSB-YP890581MOV CSB-EP890581MOV CSB-BP890581MOV CSB-MP890581MOV CSB-EP890581MOV-B |
Recombinant Macaca fascicularis Tumor necrosis factor receptor superfamily member 6 (FAS), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FAS Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-CF008433BO | Recombinant Bovine Tumor necrosis factor receptor superfamily member 6 (FAS) | in vitro E.coli expression system |
CSB-YP008433BO1 CSB-EP008433BO1 CSB-BP008433BO1 CSB-MP008433BO1 CSB-EP008433BO1-B |
Recombinant Bovine Tumor necrosis factor receptor superfamily member 6 (FAS), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FAS Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF008433MO | Recombinant Mouse Tumor necrosis factor receptor superfamily member 6 (Fas) | in vitro E.coli expression system |
CSB-YP008433MO1 CSB-EP008433MO1 CSB-BP008433MO1 CSB-MP008433MO1 CSB-EP008433MO1-B |
Recombinant Mouse Tumor necrosis factor receptor superfamily member 6 (Fas), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FAS Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-CF008433PI | Recombinant Pig Tumor necrosis factor receptor superfamily member 6 (FAS) | in vitro E.coli expression system |
CSB-YP008433PI1 CSB-EP008433PI1 CSB-BP008433PI1 CSB-MP008433PI1 CSB-EP008433PI1-B |
Recombinant Pig Tumor necrosis factor receptor superfamily member 6 (FAS), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FAS ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04542h | Human Factor-related Apoptosis,FAS ELISA Kit | serum, plasma, tissue homogenates | 7.8 pg/mL |
CSB-EL008435HU | Human Fatty acid synthase(FASN) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 0.39 ng/mL |
FAS ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E07324r | Rat Factor-related Apoptosis,FAS ELISA Kit | serum, plasma, tissue homogenates | 0.195 ng/mL |
FAS ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04543m | Mouse Factor-related Apoptosis,FAS ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 0.156 ng/mL |