Recombinant Human Tumor necrosis factor receptor superfamily member 6 protein(FAS) (Active)

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Code CSB-AP002311HU
Product Type Tumor Necrosis Factor
Size US$112Purchase it in Cusabio online store
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Uniprot No. P25445
Lead Time 5-10 business days
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Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias Apo-1 antigen, FASLG receptor, CD antigen CD95
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit the cytotoxicity of Jurkat cells is between 10-15 ug/ml in the presence of 2 ng/ml of rHuFas Ligand.
Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence RLSSKSVNAQ VTDINSKGLE LRKTVTTVET QNLEGLHHDG QFCHKPCPPG ERKARDCTVN GDEPDCVPCQ EGKEYTDKAH FSSKCRRCRL CDEGHGLEVE INCTRTQNTK CRCKPNFFCN STVCEHCDPC TKCEHGIIKE CTLTSNTKCK EEGSRSN
Research Area Cancer
Source E.coli
Gene Names FAS
Expression Region 17-173aa
Tag Info Tag-Free
Mol. Weight 17.6 kDa
Protein Description Partial
PubMed ID 1713127; 1375228; 7575433; 7533181; 8598453; 8648105; 17336828; 14702039; 15164054; 15489334; 7538908; 10542291; 10535980; 14759258; 15465831; 18691976; 18669648; 19159218; 21109225; 20068231; 21269460; 22171320; 24275569; 8967952; 19118384; 7540117; 8929
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Function Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Involvement in disease Autoimmune lymphoproliferative syndrome 1A (ALPS1A)
Subcellular Location Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Secreted, SUBCELLULAR LOCATION: Isoform 3: Secreted, SUBCELLULAR LOCATION: Isoform 4: Secreted, SUBCELLULAR LOCATION: Isoform 5: Secreted, SUBCELLULAR LOCATION: Isoform 6: Secreted
Tissue Specificity Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
Database Links

HGNC: 11920

OMIM: 134637

KEGG: hsa:355

STRING: 9606.ENSP00000347979

UniGene: Hs.244139

Pathway MAPK signaling pathway
p53 signaling pathway
TNF signaling pathway
Apoptosis
Necroptosis
Natural killer cell mediated cytotoxicity

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