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FAS, also called CD95, binds to its cognate ligand CD95L, triggering signal transduction involving FADD-mediated recruitment and activation of caspase-8 that results in apoptosis. CD95-CD95L-mediated apoptosis plays a prominent role in immune homeostasis. The CD95-CD95L pathway is essential not only for T cell death, but also for the deletion of autoreactive B cells, B cell somatic hypermutation, cytotoxicity of NK and CD8 T cells, endothelial cell apoptosis, myeloid suppressor cell turnover regulation, and activation of macrophages' functions against infections.The recombinant FAS antibody was produced by cloning antibody genes into an expression vectors, which were subsequently introduced into mammalian cells to provide animal-free antibody production. This FAS antibody has been validated in ELISA, WB, IHC. It has the features of improved affinity, stability, and consistency between different batches.
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