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| Code | CSB-CF008433HU(A4) |
| Product Type | Transmembrane Protein |
| Size | Pls inquiry other sizes |
| Uniprot No. | P25445 |
| Image |
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| Storage Buffer | Tris-based buffer，50% glycerol |
| Species | Homo sapiens (Human) |
| Purity | Greater than 85% as determined by SDS-PAGE. |
| Sequence | QVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCHKPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCTRTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKECTLTSNTKCKEEGSRSNLGWLCLLLLPIPLIVWVKRKEVQKTCRKHRKENQGSHESPTLNPETVAINLSDVDLSKYITTIAGVMTLSQVKGFVRKNGVNEAKIDEIKNDNVQDTAEQKVQLLRNWHQLHGKKEAYDTLIKDLKKANLCTLAEKIQTIILKDITSDSENSNFRNEIQSLV |
| Research Area | Cell Biology |
| Source | in vitro E.coli expression system |
| Gene Names | FAS |
| Protein Names | Recommended name: Tumor necrosis factor receptor superfamily member 6Alternative name(s): Apo-1 antigen Apoptosis-mediating surface antigen FAS FASLG receptor CD_antigen= CD95 |
| Expression Region | 26-335aa |
| Tag Info | N-terminal 10xHis-tagged |
| Mol. Weight | 40.6 kDa |
| Protein Description | Full Length of Mature Protein |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). |
| Involvement in disease | Autoimmune lymphoproliferative syndrome 1A (ALPS1A) |
| Subcellular Location | Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Secreted, SUBCELLULAR LOCATION: Isoform 3: Secreted, SUBCELLULAR LOCATION: Isoform 4: Secreted, SUBCELLULAR LOCATION: Isoform 5: Secreted, SUBCELLULAR LOCATION: Isoform 6: Secreted |
| Tissue Specificity | Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. |
| Database Links |
HGNC: 11920 OMIM: 134637 KEGG: hsa:355 STRING: 9606.ENSP00000347979 UniGene: Hs.244139 |
| Pathway |
MAPK signaling pathway
p53 signaling pathway TNF signaling pathway Apoptosis Necroptosis Natural killer cell mediated cytotoxicity |
FAS Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA06354C0Rb | FAS Antibody, FITC conjugated | Human | ELISA |
| CSB-PA06354B0Rb | FAS Antibody, HRP conjugated | Human | ELISA |
| CSB-PA06354D0Rb | FAS Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA146193 | FAS Antibody | Human | ELISA,WB |
| CSB-PA942791 | FAS Antibody | Human | ELISA,WB,IHC |
| CSB-PA001488 | FAS Antibody | Human | WB,IHC,ELISA |
| CSB-PA002481 | FAS Antibody | Human | WB,IF,ELISA |
| CSB-PA006041 | FAS Antibody | Human | WB,ELISA |
| CSB-PA009527 | Phospho-FAS (Y291) Antibody | Human | IF,ELISA |
| CSB-PA185779 | FAS Antibody | Human | ELISA,WB,IHC |
FAS Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA06354A0Rb | FAS Antibody | Human | ELISA, IHC, IF |
FAS Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP008433HU CSB-EP008433HU CSB-BP008433HU CSB-MP008433HU |
Recombinant Human Tumor necrosis factor receptor superfamily member 6(FAS),partial | Yeast E.coli Baculovirus Mammalian cell |
| CSB-AP002311HU | Recombinant Human Tumor necrosis factor receptor superfamily member 6 protein(FAS) (Active) | E.coli |
FAS ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E04542h | Human Factor-related Apoptosis,FAS ELISA Kit | serum, plasma, tissue homogenates | 7.8 pg/mL |
Recombinant Mouse Metalloproteinase inhibitor 1(Timp1)
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Human Cyclic AMP-dependent transcription factor ATF-7(ATF7)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Thrombopoietin receptor(MPL),partial
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Mouse Tumor necrosis factor receptor superfamily member 4(Tnfrsf4),partial
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Human DNA primase small subunit(PRIM1)
Express system: E.coli
Species: Homo sapiens (Human)
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