Phospho-GRIA4 (S862) Antibody

Code CSB-PA008958
Size US$100
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Product Details

Uniprot No.
Target Names
GRIA4
Alternative Names
AMPA 4 antibody; AMPA selective glutamate receptor 4 antibody; AMPA-selective glutamate receptor 4 antibody; AMPA4 antibody; GluA 4 antibody; GluA4 antibody; GluR 4 antibody; GluR D antibody; GluR-4 antibody; GluR-D antibody; GluR4 antibody; GLUR4C antibody; GLURD antibody; Glutamate receptor 4 antibody; Glutamate receptor ionotrophic AMPA 4 antibody; Glutamate receptor ionotropic antibody; GRIA 4 antibody; Gria4 antibody; GRIA4_HUMAN antibody; Ionotropic Glutamate receptor 4 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from Human GluR4 around the phosphorylation site of S862.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Gene References into Functions
  1. The authors suggest that pathogenic de novo variants in GRIA4 lead to intellectual disability with or without seizures, gait abnormalities, problems of social behavior, and other variable features. PMID: 29220673
  2. Study shows that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluA4 is expressed on oligodendrocytes, myelin and on axons in humans. PMID: 27443784
  3. This study demonstrated that the GRIA4 protein was altered in auditory cortex patient with schizophreia. PMID: 25433904
  4. Interaction with the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR4. PMID: 24962026
  5. Did not observed any significant association between GRIA4 polymorphisms and clinical improvement in patients with Major depressive disorder. PMID: 22057216
  6. SNPs within GRIA4 may not be associated with the development and treatment outcomes in BD PMID: 22122651
  7. No significant association GRIA4 polymorphisms was found with the diagnosis of schizophrenia. PMID: 22094384
  8. characterization of homomeric alpha-amino-3-hydroxy-5-methylisoxazolepropionate (AMPA)-selective GluR-D glutamate receptors carrying N-terminal deletions PMID: 12393905
  9. Results suggest that at least one susceptibility locus for schizophrenia is located within or very close to the GRIA4 region in Japanese. PMID: 12497607
  10. alternative splicing isoform of GluR4, human GluR4c has a 113-bp insert containing a stop codon, resulting in a short C terminus. PMID: 15306133
  11. The minimal kinetic mechanism for channel opening is consistent with binding of two glutamate molecules per receptor complex. PMID: 15823042
  12. GluR4 may regulate its synaptic targeting through phosphorylation-dependent interactions with alpha-Actinin-1 and IQGAP1 PMID: 16190873
  13. The present findings show that the interaction between PKCgamma and GluR4 is specifically required to assure PKC-driven phosphorylation and surface membrane expression of GluR4. PMID: 17233759

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Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite.
Protein Families
Glutamate-gated ion channel (TC 1.A.10.1) family, GRIA4 subfamily
Database Links

HGNC: 4574

OMIM: 138246

KEGG: hsa:2893

STRING: 9606.ENSP00000282499

UniGene: Hs.503743

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