RPS6KB2 Antibody

Datasheet

Code	CSB-PA02905A0Rb
Size	US$166
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Image	Western blot All lanes: RPS6KB2 antibody at 2µg/ml Lane 1: EC109 whole cell lysate Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/15000 dilution Predicted band size: 54, 17 kDa Observed band size: 54 kDa Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA02905A0Rb at dilution of 1:100
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RPS6KB2 Polyclonal antibody

Uniprot No.

Q9UBS0

Target Names

RPS6KB2

Alternative Names

70 kDa ribosomal protein S6 kinase 2 antibody; EC 2.7.11.1 antibody; KS6B2_HUMAN antibody; p70 beta antibody; p70 ribosomal S6 kinase beta antibody; p70 S6 kinase beta antibody; p70 S6K-beta antibody; p70 S6KB antibody; p70 S6Kbeta antibody; p70(S6K) beta antibody; p70-beta antibody; p70-S6K 2 antibody; P70S6K2 antibody; p70S6Kb antibody; Ribosomal protein S6 kinase 70kDa; polypeptide 2 antibody; Ribosomal protein S6 kinase B2 antibody; Ribosomal protein S6 kinase beta 2 antibody; Ribosomal protein S6 kinase beta-2 antibody; Rps6kb2 antibody; S6 kinase related kinase antibody; S6 kinase-related kinase antibody; S6K beta 2 antibody; S6K beta antibody; S6K-beta antibody; S6K-beta-2 antibody; S6K2 antibody; Serine/threonine protein kinase 14 beta antibody; Serine/threonine-protein kinase 14B antibody; SRK antibody; STK14B antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Ribosomal protein S6 kinase beta-2 protein (1-210AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The RPS6KB2 Antibody (Product code: CSB-PA02905A0Rb) is Non-conjugated. For RPS6KB2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA02905B0Rb	RPS6KB2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA02905C0Rb	RPS6KB2 Antibody, FITC conjugated
Biotin	CSB-PA02905D0Rb	RPS6KB2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Phosphorylates specifically ribosomal protein S6. Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7.

Gene References into Functions

Overexpression of catalytically-active Akt or knockdown of glycogen synthase kinase-3 (GSK3)-beta, a substrate for Akt, had little effect on Mcl-1 downregulation caused by S6K2 deficiency PMID: 28301598
We propose that the S6K2/TRBP node controls miRNA biogenesis in HDLECs and provides a molecular link between the mTOR pathway and the miRNA biogenesis machinery. PMID: 27407113
discovered that ERBB4 and S6K2 were the direct targets of miR-193a-3p and that PIK3R3 and mTOR were the direct targets of miR-193a-5p in non-small-cell lung cancer PMID: 24469061
Degradation of Tiam1 by casein kinase 1 and the SCFbetaTrCP ubiquitin ligase controls the duration of mTOR-S6K signaling. PMID: 25124033
The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer. PMID: 24131622
The p85 S6K1 promotes H2O2-induced cell death via a rapamycin-insensitive mechanism. PMID: 22955948
S6K2 amplification was frequently observed in gastric cancer and was related to a poor prognosis PMID: 23393338
Study shows that the two homologues of S6K have distinct effects on Akt activation and cell survivalin breast cancer. PMID: 21427355
heterogeneous ribonucleoprotein F is involved in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway PMID: 20308064
p70 S6 kinase regulates neutrophilic differentiation in HL-60 cells PMID: 12176053
regulation of nucleocytoplasmic shuttling of S6KbetaII by protein kinase C-mediated phosphorylation PMID: 12529391
the PI3K/p70 S6K/c-Myc cascade plays an important role in neutrophilic proliferation in HL-60 cells. PMID: 12818373
These data suggest that activated p70 S6 kinase could mediate an up-regulation of tau translation. PMID: 12875979
p70 ribosomal protein S6 kinase activity was induced by K-Ras in a phosphatidylinositol 3-kinase and mTOR-dependent manner. PMID: 14729629
S6K2 is active throughout the cell cycle with higher activity in G2 and M phases. PMID: 17786541

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily

Database Links

HGNC: 10437

OMIM: 608939

KEGG: hsa:6199

STRING: 9606.ENSP00000308413

UniGene: Hs.534345

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

ErbB signaling pathway HIF-1 signaling pathway mTOR signaling pathway PI3K-Akt signaling pathway TGF-beta signaling pathway Autophagy Fc gamma R-mediated phagocytosis AMPK signaling Apelin signaling pathway Insulin signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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