S100B Antibody

Datasheet
Code CSB-PA020643GA01HU
Size US$685
Uniprot No. P04271
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Human S100B
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB,IHC
Form Liquid
Storage Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20℃, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity purified
Isotype IgG
Alias S100 calcium binding protein B;S100B;NEF;S100;S100beta ;
Immunogen Species Human
Target Names S100B
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
Subcellular Location Cytoplasm, Nucleus
Protein Families S-100 family
Tissue Specificity Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.
Database Links

HGNC: 10500

OMIM: 176990

KEGG: hsa:6285

STRING: 9606.ENSP00000291700

UniGene: Hs.422181

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