SIPA1 Antibody

Datasheet

Code	CSB-PA021330LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: HL60 whole cell lysate All lanes: SIPA1 antibody at 2.7μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 112 kDa Observed band size: 130 kDa Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA021330LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA021330LA01HU at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA021330LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SIPA1 Polyclonal antibody

Uniprot No.

Q96FS4

Target Names

SIPA1

Alternative Names

GTPase activating protein Spa 1 antibody; GTPase-activating protein Spa-1 antibody; MGC102688 antibody; MGC17037 antibody; p130 SPA-1 antibody; p130 SPA1 antibody; Signal induced proliferation associated 1 antibody; Signal induced proliferation associated gene 1 antibody; Signal induced proliferation associated protein 1 antibody; Signal-induced proliferation-associated protein 1 antibody; SIPA 1 antibody; Sipa-1 antibody; Sipa1 antibody; SIPA1_HUMAN antibody; Spa1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Signal-induced proliferation-associated protein 1 protein (759-927AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SIPA1 Antibody (Product code: CSB-PA021330LA01HU) is Non-conjugated. For SIPA1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA021330LB01HU	SIPA1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA021330LC01HU	SIPA1 Antibody, FITC conjugated
Biotin	CSB-PA021330LD01HU	SIPA1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression.

Gene References into Functions

SIPA1 promotes oral squamous cell carcinoma metastasis by regulating the ITGB1 and MMP7. PMID: 28237246
Study shows that SIPA1 mRNA and protein expression are down-regulated in gastric cancer cells and correlate with tumor grading, invasion and lymph node metastasis as well as higher expression of VEGFA. Low SIPA1 levels in gastric cancer may then accelerate tumor development and progression by promoting VEGFA expression to increase vascular density. PMID: 28362978
results suggest that SIPA1 and RRP1B germline polymorphisms are important for breast cancer prognosis PMID: 26901824
Our results indicate, for the first time, that the SIPA1 -313A>G may have a prognostic role in unresected NSCLC making it a potential predictor of poor survival due to earlier progression. PMID: 25352027
nuclear SIPA1 contributes to breast cancer cell invasion through the regulation of integrin beta1 signaling. PMID: 24704834
BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane. PMID: 24260471
This meta-analysis suggests that rs746429 is associated with the risk of breast cancer. PMID: 24006220
SIPA1 SNPs, rs746429 and rs2306364, were associated with decreased risk of triple-negative breast tumors. PMID: 23771732
Polymorphism in Sipa1 promoter gene is associated with lung cancer. PMID: 23661532
Patients with metastatic breast cancer with SIPA1 545 T/T genotype had a significantly worse overall survival than did patients with C/T or C/C genotype (50.0% vs. 62.9%, P = 0.042). PMID: 23358895
SIPA1 expression is increased in human colorectal cancer. PMID: 22990111
In this case-control study, SNPs in SIPA1 varied statistically in cervical cancer patients with and without nodal metastases and in MMP9 after controlling for stage and lymphvascular space invasion. PMID: 19906411
Data identif a Rap GTPase-activating protein, signal-induced proliferation-associated protein 1 (SPA-1), as a factor that interacts with Brd4. PMID: 15456879
SIPA1 germline polymorphisms are associated with aggressive disease behavior in breast cancer. PMID: 16563182
SPA1 regulates the maintenance and differentiation of embryonic stem cells. PMID: 18033671
it is unlikely that SIPA1 plays a pathogenetic role in the development of juvenile myelomonocytic leukemia PMID: 18492118
Our results do not support a relationship between SIPA1 polymorphisms and breast cancer risk or subsequent survival PMID: 19089925
SIPA1 SNP rs3741378 was associated with increased breast cancer incidence. PMID: 19765277

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Subcellular Location

Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein.

Tissue Specificity

Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.

Database Links

HGNC: 10885

OMIM: 602180

KEGG: hsa:6494

STRING: 9606.ENSP00000377771

UniGene: Hs.530477

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Leukocyte transendothelial migration Rap1 signaling pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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