SLC1A2 Antibody

Datasheet
Code CSB-PA109577
Former Code(s) CSB-PA141398
Size US$299
Uniprot No. P43004
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA109577(SLC1A2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA109577(SLC1A2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Synthetic peptide of Human SLC1A2
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,IHC;ELISA:1:1000-1:5000,IHC:1:25-1:100
Relevance This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias solute carrier family 1 (glial high affinity glutamate transporter), member 2
Immunogen Species Homo sapiens (Human)
Target Names SLC1A2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate
Involvement in disease Epileptic encephalopathy, early infantile, 41 (EIEE41)
Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family, SLC1A2 subfamily
Database Links

HGNC: 10940

OMIM: 600300

KEGG: hsa:6506

STRING: 9606.ENSP00000278379

UniGene: Hs.502338

Pathway Glutamatergic synapse

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