STEAP2 Antibody

Code CSB-PA008693
Size US$100
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Product Details

Uniprot No.
Target Names
STEAP2
Alternative Names
STEAP2; PCANAP1; STAMP1; UNQ6507/PRO23203; Metalloreductase STEAP2; Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; PUMPCn; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from the C-terminal region of Human STEAP2.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.
Gene References into Functions
  1. Over-expression of STEAP2 is associated with prostate cancer progression. PMID: 25248617
  2. Data suggest that STAMP1 is required for prostate cancer growth. PMID: 20587517
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
  4. cloning and characterization of STAMP1, which is expressed in both normal prostate and prostate neoplasms PMID: 12095985
  5. STEAP2 is involved in the development of prostate cancer. As a cell-surface antigen, it is a potential diagnostic or therapeutic target in prostate cancer. PMID: 12429817
  6. Expression of STAMP2, a gene highly similar to STAMP1 (STEAP2), in prostate cancer cells significantly increases cell growth and colony formation suggesting that STAMP2 may have a role in cell proliferation. PMID: 15897894
  7. STEAPs may represent novel markers of mesenchymal stem cells in man as well as mice. PMID: 19196137
  8. The murine ortholog, Steap2, is a ferrireductase, cupric reductase, and stimulates cellular uptake of both iron and copper in vitro. PMID: 16609065

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Subcellular Location
Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein Families
STEAP family
Tissue Specificity
Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.
Database Links

HGNC: 17885

OMIM: 605094

KEGG: hsa:261729

STRING: 9606.ENSP00000287908

UniGene: Hs.489051

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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