STEAP2 Antibody

Datasheet

Code	CSB-PA275156
Size	US$297
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Image	Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using STEA2 antibody. Immunofluorescence analysis of A549 cells, using STEA2 antibody.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) STEAP2 Polyclonal antibody

Uniprot No.

Q8NFT2

Target Names

STEAP2

Alternative Names

STEAP2; PCANAP1; STAMP1; UNQ6507/PRO23203; Metalloreductase STEAP2; Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; PUMPCn; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from C-terminal of Human STEA2.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

ELISA,IHC,IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:50-1:100
IF	1:100-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.

Gene References into Functions

Over-expression of STEAP2 is associated with prostate cancer progression. PMID: 25248617
Data suggest that STAMP1 is required for prostate cancer growth. PMID: 20587517
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
cloning and characterization of STAMP1, which is expressed in both normal prostate and prostate neoplasms PMID: 12095985
STEAP2 is involved in the development of prostate cancer. As a cell-surface antigen, it is a potential diagnostic or therapeutic target in prostate cancer. PMID: 12429817
Expression of STAMP2, a gene highly similar to STAMP1 (STEAP2), in prostate cancer cells significantly increases cell growth and colony formation suggesting that STAMP2 may have a role in cell proliferation. PMID: 15897894
STEAPs may represent novel markers of mesenchymal stem cells in man as well as mice. PMID: 19196137
The murine ortholog, Steap2, is a ferrireductase, cupric reductase, and stimulates cellular uptake of both iron and copper in vitro. PMID: 16609065

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Subcellular Location

Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Protein Families

STEAP family

Tissue Specificity

Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.

Database Links

HGNC: 17885

OMIM: 605094

KEGG: hsa:261729

STRING: 9606.ENSP00000287908

UniGene: Hs.489051

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Target Therapy

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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