Recombinant Human Metalloreductase STEAP2 (STEAP2)

Code CSB-CF854119HU
Size US$2345
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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Product Details

Greater than 90% as determined by SDS-PAGE.
Target Names
Uniprot No.
Research Area
Alternative Names
STEAP2; PCANAP1; STAMP1; UNQ6507/PRO23203; Metalloreductase STEAP2; Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; PUMPCn; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1
Homo sapiens (Human)
in vitro E.coli expression system
Expression Region
Target Protein Sequence
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight
Protein Length
Full Length
Tag Info
N-terminal 10xHis-SUMO-tagged
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.

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Target Background

Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.
Gene References into Functions
  1. Over-expression of STEAP2 is associated with prostate cancer progression. PMID: 25248617
  2. Data suggest that STAMP1 is required for prostate cancer growth. PMID: 20587517
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
  4. cloning and characterization of STAMP1, which is expressed in both normal prostate and prostate neoplasms PMID: 12095985
  5. STEAP2 is involved in the development of prostate cancer. As a cell-surface antigen, it is a potential diagnostic or therapeutic target in prostate cancer. PMID: 12429817
  6. Expression of STAMP2, a gene highly similar to STAMP1 (STEAP2), in prostate cancer cells significantly increases cell growth and colony formation suggesting that STAMP2 may have a role in cell proliferation. PMID: 15897894
  7. STEAPs may represent novel markers of mesenchymal stem cells in man as well as mice. PMID: 19196137
  8. The murine ortholog, Steap2, is a ferrireductase, cupric reductase, and stimulates cellular uptake of both iron and copper in vitro. PMID: 16609065

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Subcellular Location
Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein Families
STEAP family
Tissue Specificity
Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.
Database Links

HGNC: 17885

OMIM: 605094

KEGG: hsa:261729

STRING: 9606.ENSP00000287908

UniGene: Hs.489051

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