STEAP2 Recombinant Monoclonal Antibody

Datasheet

Code	CSB-RA854119MA1HU
Size	US$210
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Image	Overlay Peak curve showing PC-3 cells stained with CSB-RA854119MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/110⁶cells) for 45min at 4℃. The secondary antibody used was Fluorescein (FITC) AffiniPure Goat Anti-Human IgG, Fcγ fragment specific at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG1 (1ug/110⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q8NFT2

Target Names

STEAP2

Alternative Names

4921538B17Rik antibody; AI930049 antibody; IPCA 1 antibody; IPCA1 antibody; Metalloreductase STEAP2 antibody; PCANAP 1 antibody; PCANAP1 antibody; Prostate cancer associated protein 1 antibody; Prostate cancer-associated protein 1 antibody; Protein up regulated in metastatic prostate cancer antibody; Protein upregulated in metastatic prostate cancer antibody; PUMPCn antibody; Six transmembrane epithelial antigen of prostate 2 antibody; Six transmembrane epithelial antigen of the prostate 2 antibody; Six-transmembrane epithelial antigen of prostate 2 antibody; SixTransMembrane protein of prostate 1 antibody; STAMP 1 antibody; STAMP1 antibody; STEA2_HUMAN antibody; STEAP 2 antibody; STEAP family member 2; metalloreductase antibody; Steap2 antibody; STMP antibody; UNQ6507/PRO23203 antibody

Species Reactivity

Human

Immunogen

Recombinant Human STEAP2 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Isotype

hIgG1

Clone No.

6B3

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, FC

Recommended Dilution

Application	Recommended Dilution
FC	1:50-1:200

Protocols

ELISA Protocol
Flow Cytometry (FC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.

Gene References into Functions

Over-expression of STEAP2 is associated with prostate cancer progression. PMID: 25248617
Data suggest that STAMP1 is required for prostate cancer growth. PMID: 20587517
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
cloning and characterization of STAMP1, which is expressed in both normal prostate and prostate neoplasms PMID: 12095985
STEAP2 is involved in the development of prostate cancer. As a cell-surface antigen, it is a potential diagnostic or therapeutic target in prostate cancer. PMID: 12429817
Expression of STAMP2, a gene highly similar to STAMP1 (STEAP2), in prostate cancer cells significantly increases cell growth and colony formation suggesting that STAMP2 may have a role in cell proliferation. PMID: 15897894
STEAPs may represent novel markers of mesenchymal stem cells in man as well as mice. PMID: 19196137
The murine ortholog, Steap2, is a ferrireductase, cupric reductase, and stimulates cellular uptake of both iron and copper in vitro. PMID: 16609065

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Subcellular Location

Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Protein Families

STEAP family

Tissue Specificity

Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.

Database Links

HGNC: 17885

OMIM: 605094

KEGG: hsa:261729

STRING: 9606.ENSP00000287908

UniGene: Hs.489051

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Target Therapy

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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