TGFB1 Antibody

Datasheet
Code CSB-PA786987
Product Type Polyclonal Antibody
Size US$295
Uniprot No. P01137
Image
  • Western blot analysis of extracts from HepG2 cells, using TGF beta Antibody. The lane on the left is treated with the synthesized peptide.
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen The antiserum was produced against synthesized peptide derived from Human TGF beta.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Specificity TGF beta1 Antibody detects endogenous levels of total TGF beta protein.
Tested Applications ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200
Relevance

 Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors.

Form 1mg/ml in PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol
Purification Method Affinity-chromatography
Clonality Polyclonal
Alias CED; diaphyseal dysplasia 1, progressive; DPD1; TGF-beta 1; TGFB.TGF-BETA
Immunogen Species Homo sapiens (Human)
Target Names TGFB1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP)
Involvement in disease Camurati-Engelmann disease (CAEND)
Subcellular Location Secreted, extracellular space, extracellular matrix
Protein Families TGF-beta family
Tissue Specificity Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage.
Database Links

HGNC: 11766

OMIM: 131300

KEGG: hsa:7040

STRING: 9606.ENSP00000221930

UniGene: Hs.645227

Pathway Hippo signaling pathway
MAPK signaling pathway
TGF-beta signaling pathway
Cell cycle
Cellular senescence
Osteoclast differentiation
Th17 cell differentiation
AGE-RAGE signaling pathway in diabetic complications
FoxO signaling pathway

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