TP73 Antibody

Datasheet
Code CSB-PA615731
Size US$299
Uniprot No. O15350
Image
  • Gel: 10%SDS-PAGE, Lysate: 60 μg, Lane 1-2: Human fetal muscle tissue, 231 cells, Primary antibody: CSB-PA615731(TP73 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Fusion protein of Human TP73
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications ELISA,WB;ELISA:1:1000-1:2000,WB:1:200-1:1000
Relevance This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias tumor protein p73
Immunogen Species Homo sapiens (Human)
Target Names TP73
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
Subcellular Location Nucleus, Cytoplasm
Protein Families P53 family
Tissue Specificity Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue.
Database Links

HGNC: 12003

OMIM: 601990

KEGG: hsa:7161

STRING: 9606.ENSP00000367545

UniGene: Hs.192132

Pathway Hippo signaling pathway
p53 signaling pathway
Neurotrophin signaling pathway

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