TSC2 Antibody, Biotin conjugated

Datasheet
Code CSB-PA343033LD01HU
Size US$299
Uniprot No. P49815
Protocols ELISA Protocol
Immunogen Recombinant Human Tuberin protein (1396-1496AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Tuberin (Tuberous sclerosis 2 protein), TSC2, TSC4
Immunogen Species Human
Research Area Cell Biology
Target Names TSC2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.
Involvement in disease Tuberous sclerosis 2 (TSC2); Lymphangioleiomyomatosis (LAM); Focal cortical dysplasia 2 (FCORD2)
Subcellular Location Cytoplasm, Membrane, Peripheral membrane protein
Tissue Specificity Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.
Database Links

HGNC: 12363

OMIM: 191092

KEGG: hsa:7249

STRING: 9606.ENSP00000219476

UniGene: Hs.90303

Pathway mTOR signaling pathway
p53 signaling pathway
PI3K-Akt signaling pathway
Autophagy
Cellular senescence
MAPK Erk pathway
AMPK signaling
Insulin signaling pathway
Oxidative Phosphorylation
Phospholipase D signaling pathway

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