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| Code | CSB-PA880966LB01HU |
| Size | US$299 |
| Uniprot No. | Q9H3M7 |
| Protocols | ELISA Protocol |
| Immunogen | Recombinant Human Thioredoxin-interacting protein (299-381AA) |
| Raised in | Rabbit |
| Species Reactivity | Human |
| Tested Applications | ELISA |
| Relevance | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). |
| Form | Liquid |
| Conjugate | HRP |
| Storage Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method | >95%, Protein G purified |
| Isotype | IgG |
| Clonality | Polyclonal |
| Alias | Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1), TXNIP, VDUP1 |
| Immunogen Species | Homo sapiens (Human) |
| Research Area | Signal Transduction |
| Target Names | TXNIP |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
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| Function | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). |
| Subcellular Location | Cytoplasm |
| Protein Families | Arrestin family |
| Database Links |
HGNC: 16952 OMIM: 606599 KEGG: hsa:10628 STRING: 9606.ENSP00000358323 UniGene: Hs.533977 |
| Pathway |
Inflammasome Signaling
NOD-like receptor signaling pathway |
TXNIP Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA880966LA01HU | TXNIP Antibody | Human | ELISA, IF |
TXNIP Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA880966LC01HU | TXNIP Antibody, FITC conjugated | Human | ELISA |
| CSB-PA880966LD01HU | TXNIP Antibody, Biotin conjugated | Human | ELISA |
TXNIP Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP880966HU CSB-EP880966HU CSB-BP880966HU CSB-MP880966HU |
Recombinant Human Thioredoxin-interacting protein(TXNIP) | Yeast E.coli Baculovirus Mammalian cell |
| CSB-CF880966HUa6 | Recombinant Thioredoxin-interacting protein(TXNIP) | in vitro E.coli expression system |
| CSB-CF880966HU | Recombinant Thioredoxin-interacting protein(TXNIP) | in vitro E.coli expression system |
TXNIP ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-EL025383HU | Human Thioredoxin-interacting protein(TXNIP) ELISA kit | serum, plasma, tissue homogenates | 3.9 pg/mL |
2-hydroxyisobutyryl-HIST1H2BC (K34) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H3A (K4) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H4A (K16) Antibody
Applications: ELISA, WB, IF, IP, ChIP
Species Reactivity: Human
