Tf Antibody

Code CSB-PA00470E0Rb
Size US$166
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Image
  • Western blot
    All lanes: Rat Transferrin antibody at 2µg/ml
    Lane 1: Rat Transferrin at 0.2 mg
    Lane 2: Rat Transferrin at 0.1 mg
    Secondary
    Goat polyclonal to rabbit IgG at 1/15000 dilution
    Predicted band size: 77, 55 kDa
    Observed band size: 77 kDa
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Tf Polyclonal antibody
Uniprot No.
Target Names
Tf
Alternative Names
Tf antibody; Serotransferrin antibody; Transferrin antibody; Beta-1 metal-binding globulin antibody; Liver regeneration-related protein LRRG03 antibody; Siderophilin antibody
Raised in
Rabbit
Species Reactivity
Rat
Immunogen
Rat Transferrin (Native Protein)
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Non-conjugated

The Tf Antibody (Product code: CSB-PA00470E0Rb) is Non-conjugated. For Tf Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA00470F0Rb Tf Antibody, HRP conjugated ELISA
FITC CSB-PA00470G0Rb Tf Antibody, FITC conjugated
Biotin CSB-PA00470H0Rb Tf Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
Gene References into Functions
  1. our data establish that blood TSAT exerts a critical role in experimental stroke-induced brain damage. In addition, our findings suggest that the protective effect of iron-free transferrin (apotransferrin, ATf) at the neuronal level resides in preventing NMDA-induced HTf uptake and ROS production, which in turn reduces neuronal damage PMID: 29248829
  2. In brain interstitial fluid, transferrin-bound iron and non-transferrin-bound iron (NTBI) exist as potential iron sources PMID: 25649872
  3. Transferrin and thyroid hormone converge to regulate oligodendrocyte maturation and myelinogenesis. PMID: 25595122
  4. This evidence supports a key role of Tf on the generation of oligodendrocytes (OLs) from Neural stem and progenitor cells (NSC/NPCs)and highlights its potential in demyelinating disorder treatment. PMID: 22479482
  5. Transferrin is involved in the uptake of the radiopharmaceutical gallium-67 (67Ga) by regenerating liver tissue following partial hepatectomy but is not involved in the entry of 67Ga into hepatocytes. PMID: 11767098
  6. data show that brain cells have the capacity to maintain minimum iron levels during iron deficiency which may be associated with increased iron-Tf uptake, stabilization of TfR mRNA, or increased Tf mRNA translation efficiency in specific cell types PMID: 12608731
  7. effects of apotransferrin occur early in development during a narrow, transient "temporal window" within which oligodendroglia are sensitive to its action. PMID: 12730961
  8. first report describing presence of serotransferrin precursor protein homolog belonging to transferrin family and sharing epitopes with melanotransferrin in adrenal, its induction by ACTH, and sensitivity to ginkgolide B (adrenotransferrin). PMID: 14701678
  9. compared to transferrin, soluble melanotransferrin plays little or no role in Fe supply to the brain and erythropoietic tissue PMID: 15469901
  10. in addition to hemoglobin-bound iron, Tf-bound iron may contribute to intracerebral hemorrhage-induced brain injury and thrombin may contribute to the latter by facilitating cellular iron uptake PMID: 15637325
  11. Our studies suggest that AEC I is not just a simple barrier for gas exchange, but a functional cell that protects alveolar epithelium from injury. PMID: 16497717
  12. Plays role in maturation of Schwann cells(SC) in physiological conditions as well as in role in facilitating clearance of myelin debris and subsequent nerve regeneration and/or in SC phenotypic change, which led to survival after peripheral nerve injury. PMID: 17628542
  13. Apotransferrin added to oligodendroglial cell cultures can correct the effects of iron deficiency. PMID: 18459135
  14. serotransferrin levels were increased in diestrous as compared with proestrous, estrous, metestrous PMID: 18511206
  15. we have discovered a novel mitochondrial iron transport system that goes awry in Parkinson's disease, and which may provide a new target for therapeutic intervention. PMID: 19250966
  16. synthesis and secretion of transferrin in rat parotid acinar cells PMID: 19464997

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Subcellular Location
Secreted.
Protein Families
Transferrin family
Tissue Specificity
Expressed by the liver and secreted in plasma.
Database Links
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