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VDAC3 Antibody

Datasheet
Code CSB-PA896484LA01HU
Size US$166
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Image
  • Western Blot
    Positive WB detected in: K562 whole cell lysate,A549 whole cell lysate,293 whole cell lysate,U251 whole cell lysate,HL-60 whole cell lysate,Hela whole cell lysate
    All lanes: VDAC3 antibody at 1:1000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 31 kDa
    Observed band size: 32 kDa
  • Immunofluorescence staining of Hela cells with CSB-PA896484LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) VDAC3 Polyclonal antibody
Uniprot No.
Q9Y277
Target Names
VDAC3
Alternative Names
Voltage-dependent anion-selective channel protein 3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3), VDAC3
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Voltage-dependent anion-selective channel protein 3 protein (40-160aa)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The VDAC3 Antibody (Product code: CSB-PA896484LA01HU) is Non-conjugated. For VDAC3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA896484LB01HU VDAC3 Antibody, HRP conjugated ELISA
FITC CSB-PA896484LC01HU VDAC3 Antibody, FITC conjugated
Biotin CSB-PA896484LD01HU VDAC3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IF 1:50-1:500
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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VDAC3 Antibodies

VDAC3 Proteins

Customer Reviews and Q&A

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Target Background

Function
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
Gene References into Functions
  1. The AG genotype of rs16891278 showed a significantly lower sperm concentration compared with the AA genotype (P = 0.044). Findings suggest that VDAC3 genetic variants may be associated with human sperm count. PMID: 28431403
  2. This cohort study showed that the VDAC3 gene was down regulation between patients with idiopathic Parkinson disease and controls PMID: 28916538
  3. VDAC3 is able to modulate its pore size and current by exploiting the mobility of the N-terminal and forming, upon external stimuli, disulfide bridges with cysteine residues located on the barrel and exposed to the inter-membrane space. PMID: 26806159
  4. channel gating of VDAC3 might be controlled by redox sensing under physiological conditions PMID: 26407725
  5. observed electrophysiological properties of hVDAC3 are surprisingly different from the other isoforms and are discussed in relation to the proposed physiological role of the protein in mammalian cells PMID: 25171321
  6. a VDAC3-Mps1 module at the centrosome promotes ciliary disassembly during cell cycle entry. PMID: 23388454
  7. VDAC3 is present at the mother centriole and modulates centriole assembly by recruiting Mps1 to centrosomes. PMID: 22935710
  8. VDAC3 has a limited ability to support mitochondrial respiration and has no influence in the control of ROS production. PMID: 20138821
  9. VDAC3 is a novel target for protein S-nigrosylation in spermatozoa. PMID: 17683036

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Subcellular Location
Mitochondrion outer membrane. Membrane.
Protein Families
Eukaryotic mitochondrial porin family
Tissue Specificity
Expressed in erythrocytes (at protein level). Widely expressed. Highest in testis.
Database Links

HGNC: 12674

OMIM: 610029

KEGG: hsa:7419

STRING: 9606.ENSP00000428845

UniGene: Hs.699301

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