VDAC3 Antibody

Datasheet

Code	CSB-PA896484LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: K562 whole cell lysate,A549 whole cell lysate,293 whole cell lysate,U251 whole cell lysate,HL-60 whole cell lysate,Hela whole cell lysate All lanes: VDAC3 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 31 kDa Observed band size: 32 kDa Immunofluorescence staining of Hela cells with CSB-PA896484LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) VDAC3 Polyclonal antibody

Uniprot No.

Q9Y277

Target Names

VDAC3

Alternative Names

Voltage-dependent anion-selective channel protein 3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3), VDAC3

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Voltage-dependent anion-selective channel protein 3 protein (40-160aa)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The VDAC3 Antibody (Product code: CSB-PA896484LA01HU) is Non-conjugated. For VDAC3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA896484LB01HU	VDAC3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA896484LC01HU	VDAC3 Antibody, FITC conjugated
Biotin	CSB-PA896484LD01HU	VDAC3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IF	1:50-1:500

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.

Gene References into Functions

The AG genotype of rs16891278 showed a significantly lower sperm concentration compared with the AA genotype (P = 0.044). Findings suggest that VDAC3 genetic variants may be associated with human sperm count. PMID: 28431403
This cohort study showed that the VDAC3 gene was down regulation between patients with idiopathic Parkinson disease and controls PMID: 28916538
VDAC3 is able to modulate its pore size and current by exploiting the mobility of the N-terminal and forming, upon external stimuli, disulfide bridges with cysteine residues located on the barrel and exposed to the inter-membrane space. PMID: 26806159
channel gating of VDAC3 might be controlled by redox sensing under physiological conditions PMID: 26407725
observed electrophysiological properties of hVDAC3 are surprisingly different from the other isoforms and are discussed in relation to the proposed physiological role of the protein in mammalian cells PMID: 25171321
a VDAC3-Mps1 module at the centrosome promotes ciliary disassembly during cell cycle entry. PMID: 23388454
VDAC3 is present at the mother centriole and modulates centriole assembly by recruiting Mps1 to centrosomes. PMID: 22935710
VDAC3 has a limited ability to support mitochondrial respiration and has no influence in the control of ROS production. PMID: 20138821
VDAC3 is a novel target for protein S-nigrosylation in spermatozoa. PMID: 17683036

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Subcellular Location

Mitochondrion outer membrane. Membrane.

Protein Families

Eukaryotic mitochondrial porin family

Tissue Specificity

Expressed in erythrocytes (at protein level). Widely expressed. Highest in testis.

Database Links

HGNC: 12674

OMIM: 610029

KEGG: hsa:7419

STRING: 9606.ENSP00000428845

UniGene: Hs.699301

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Calcium signaling pathway Cellular senescence Necroptosis NOD-like receptor signaling pathway cGMP-PKG signaling pathway Cholesterol metabolism

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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