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| Code | CSB-PA464342LA01EXZ |
| Size | US$166 |
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The kgp Antibody (Product code: CSB-PA464342LA01EXZ) is Non-conjugated. For kgp Antibody with conjugates, please check the following table.
| Application | Recommended Dilution |
|---|---|
| WB | 1:500-1:5000 |
The kgp antibody is designed to recognize the Porphyromonas gingivalis kgp protein. When a rabbit received an injection of the recombinant Porphyromonas gingivalis Lys-gingipain protein (229-594aa), an immune response occurred in the rabbit producing large amounts of antibodies against the kgp protein. The rabbit's blood was collected and isolated to get the anti-serum, which was purified by protein G to obtain the kgp polyclonal antibody (purity 95%+). This kgp antibody has accessed its specificity in ELISA and WB applications. Lys-gingipain is a Porphyromonas gingivalis-producing protease that plays a key role in viral pathogenicity.
Lys-gingipain can cleave a wide range of host proteins, including immunoglobulins, complement proteins, and extracellular matrix proteins such as collagen and elastin, enabling them to invade and destroy host tissues leading to tissue damage and inflammation. In addition to its proteolytic activity, Lys-gingipain also has been shown to inhibit the host immune response, allowing P. gingivalis to establish a persistent infection and cause chronic periodontitis.
Applications : western blot
Sample type: cells
Review: Rgp-specific and Kgp-specific proteolytic activities were determined in whole P. gingivalis cultures grown for 24 h in iron- and heme-rich conditions (Hm) or in iron_x005fand heme-free conditions (DIP).
By Anonymous
KEGG: pgn:PGN_1728
STRING: 431947.PGN_1728
