Recombinant Chicken Brain-derived neurotrophic factor(BDNF)

Code CSB-YP002655CH
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Source Yeast
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Code CSB-EP002655CH
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Source E.coli
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Code CSB-EP002655CH-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP002655CH
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Source Baculovirus
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Code CSB-MP002655CH
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names BDNF
Uniprot No. P25429
Alternative Names BDNFBrain-derived neurotrophic factor; BDNF
Species Gallus gallus (Chicken)
Expression Region 128-246
Target Protein Sequence HSD PARRGELSVC DSTSEWVTAA EKKTAVDMSG ATVTVLEKVP VPKGQLKQYF YETKCNPKGY TKEGCRGIDK RHWNSQCRTT QSYVRALTMD NKKRVGWRFI RIDTSCVCTL TIKRGR
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Gene References into Functions
  1. The stress resilient Production Reds showed stable BDNF levels across the isolation test period whereas the vulnerable Black Australorps showed an increase in hippocampal BDNF levels PMID: 23396147
  2. Muscle cells produce and secrete proBDNF, which through its interaction with p75NTR and sortilin promotes a caspase-dependent death of motor neurons in culture. PMID: 21834083
  3. Levels of NGF, BDNF and NT-3 were all up regulated from E7 to E14 in the spinal cord of embryonic chicken during development. PMID: 19764571
  4. Blockade of spontaneous retinal activity with tetrodotoxin, or the blockade of axonal transport with colchicine, both reversed the normal mismatch between retinal BDNF mRNA and protein. PMID: 15080885
  5. BDNF expression is critically involved in thermal-experience-dependent development. PMID: 16611805
  6. These data suggest that complex and dynamic changes in DNA methylation are involved in the regulation of Bdnf expression during thermotolerance acquisition. PMID: 19046370
  7. Interactions between BDNF and the T(3) thyroid hormone and/or corticosterone may constitute a homeostatic mechanism that links hypothalamic energy regulation controlling body composition. PMID: 19158410
  8. mRNA expression level of cBDNF1 may be related to the DNA methylation status with a potential role of variant cBDNF1 in Marek disease tumor resistance and susceptibility PMID: 19269281
  9. An increase in BDNF was observed in both auditory stimulated groups. The increased levels of BDNF may help in regulating synaptic plasticity. PMID: 19559781

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Subcellular Location Secreted.
Protein Families NGF-beta family
Database Links

KEGG: gga:396186

STRING: 9031.ENSGALP00000019837

UniGene: Gga.696

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