Recombinant Human Guanine nucleotide exchange factor VAV2 (VAV2), partial

Code CSB-YP025804HU
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Source Yeast
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Code CSB-EP025804HU
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Source E.coli
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Code CSB-EP025804HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP025804HU
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Source Baculovirus
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Code CSB-MP025804HU
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Guanine nucleotide exchange factor VAV2; Oncogene VAV2; Protein vav 2; VAV 2; Vav 2 oncogene; VAV-2; VAV2; VAV2 oncogene; VAV2_HUMAN
Homo sapiens (Human)
Protein Length
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.
Gene References into Functions
  1. VAV2 polymorphisms associate with cardiovascular risk factors and target organ damage. PMID: 28157227
  2. Study found that Vav2, is overexpressed in human prostate cancer and enhanced AR and AR splicing variant activity. PMID: 28811363
  3. High VAV2 expression is associated with breast cancer. PMID: 26910843
  4. Manipulating steroidogenic factor-1 (SF-1) and nucleotide exchange factor VAV-2 (VAV2) abundance in cultured adrenocortical carcinoma (ACC) cells indicate that VAV2 was a critical factor for SF-1-induced cytoskeletal remodeling and invasion in culture and in vivo (chicken chorioallantoic membrane) models. PMID: 28270555
  5. Data indicate that phosphorylated cortactin recruits Vav2 to activate Rac3 and promote invadopodial maturation in invasive breast cancer cells. PMID: 28356423
  6. autocrine VEGF and IL-8 promoted endothelial cell migration via the Src/Vav2/Rac1/PAK1 signaling pathway. PMID: 28278510
  7. We concluded that Vav2 might promote invasion and metastasis of gastric cancer by regulating some invasion and metastasis-related genes. PMID: 28459214
  8. work suggested that EphB3 acted as a tumor promoter in Papillary Thyroid Cancer by increasing the in vitro migration as well as the in vivo metastasis of Papillary Thyroid Cancer cells through regulating the activities of Vav2 and Rho GTPases in a kinase-dependent manner. PMID: 27986811
  9. The crystal structure of the complex between a phosphorylated PPxY motif of TXNIP and the SH2 domain of Vav2 reveals a conserved recognition mechanism. PMID: 26919541
  10. Our data provide the first evidence to implicate VAV2 in glucose-induced Rac1 activation, actin remodelling and glucose-stimulated insulin secretion in pancreatic beta cells. PMID: 26224100
  11. VAV2 is required for Met signaling in the perinuclear endosome. PMID: 24835487
  12. Authors propose a model whereby vimentin promotes FAK stabilization through VAV2-mediated Rac1 activation. This model may explain why vimentin expressing metastatic lung cancer cells are more motile and invasive. PMID: 24858039
  13. Data suggest a coordination between paxillin kinase linker (PKL)/Vav2 signaling and PKL/beta-PIX signaling during cell migration. PMID: 23615439
  14. the guanine nucleotide exchange factor (GEF) Vav2 is identified as a candidate partner for KCC3. PMID: 23724134
  15. Two variants of VAV2 and VAV3, rs2156323 and rs2801219, respectively, were identified in Japanese patients with primary open angle glaucoma, normal tension glaucoma, and developmental glaucoma. PMID: 23402756
  16. Upregulation of Rac1 activity by Wnt3a temporally correlated with enhanced p120-catenin binding to Rac1 and Vav2. PMID: 22946057
  17. Studies indicate relevance of P-Rex1 and P-Rex2a, in breast tumorigenesis, and suggest that the exchange factors Vav2 and Vav3 play synergistic roles in breast cancer by sustaining tumor growth, neoangiogenesis, and metastasis. PMID: 23033535
  18. Data indicate that Vav2 and Vav3 controlled a vast transcriptional program in breast cancer cells through mechanisms that were shared between the two proteins, isoform-specific or synergistic. PMID: 23033540
  19. The structural basis for the interaction between Arap3 and Vav2, hydrophobic pockets and binding specificity. PMID: 22750419
  20. VAV2 specifically interacts with activated Galpha(q) but not with Galpha(s) subunits, competing with parathyroid hormone receptor for coupling to Galpha(q). PMID: 22554804
  21. Type IV pili producing Neisseria gonorrhoeae triggers a phosphotyrosine-dependent Cav1-Vav2-RhoA signaling cascade that elicits cytoskeletal rearrangements and effectively impedes bacterial uptake into host cells. PMID: 20808760
  22. VAV2 has been identified as a candidate gene in a genome-wide association study of German multiple sclerosis patients. PMID: 20598377
  23. present data indicate a lack of involvement of variations in NTF4, VAV2, and VAV3 with glaucoma pathogenesis in an Indian population. PMID: 20463313
  24. Data strongly suggest that VAV2 and VAV3 genes are susceptibility loci in Japanese primary open-angle glaucoma. PMID: 20140222
  25. Together, we suggest that balanced Vav2 activity is necessary for optimal neurite outgrowth and promotes branching by targeting GEF activity to branch points. PMID: 20298788
  26. Vav2 can regulate growth factors receptor signalling by slowing receptor internalization and degradation through its interaction with endosome-associated proteins. PMID: 20140013
  27. Interaction of L2 with Vav2 was mediated by the N-terminus of L2 and independent of the N-terminus of Vav2. PMID: 19451809
  28. RhoA knockdown intensified the Vav2-induced disruption of acini, leading to more aggressive cell outgrowth and branching morphogenesis. PMID: 19826000
  29. Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation. PMID: 11909943
  30. Vav2 and Tiam1 may act as downstream effectors of Src, thereby regulating Rac1-dependent pathways that participate in Src-induced cell transformation PMID: 12810717
  31. Rap1 promotes cell spreading by localizing a subset of Rac GEFs to sites of active lamellipodia extension PMID: 15479739
  32. Vav2-mediated nucleotide exchange of Rho GTPases follows the Theorell-Chance catalytic mechanism in which Vav2.Rho GTPase complex is the major species during the exchange process and Vav2.GDP-Mg2+.Rho GTPase ternary complex is present only transiently. PMID: 15850391
  33. The EGFR/Vav2/Rac1 axis is a crucial pathway for the acquisition of motile and invasive properties of most head and neck squamous cell carcinoma cells. PMID: 17234718
  34. Vav2 acts downstream of VEGF to activate Rac1. PMID: 17686471
  35. IMC-C225 cross-links integrins with EGFR, leading to Vav2-dependent activation of RhoA PMID: 18829495
  36. Vav2 is a GDP/GTP exchange factor (GEF) for Rac in vivo. PMID: 11448999

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Tissue Specificity
Widely expressed.
Database Links

HGNC: 12658

OMIM: 600428

KEGG: hsa:7410

STRING: 9606.ENSP00000360916

UniGene: Hs.369921

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