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| Product Type | Recombinant Protein |
| Uniprot No. | P05121 |
| Species | Homo sapiens (Human) |
| Gene Names | SERPINE1 |
| Protein Names | Recommended name: Plasminogen activator inhibitor 1 Short name= PAI Short name= PAI-1 Alternative name(s): Endothelial plasminogen activator inhibitor Serpin E1 |
| Storage | Store at -20°C, for extended storage, conserve at -20°C or -80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| Target Details | This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| HGNC | 8583 |
| RGD | 3249 |
| MGI | 97608 |
| Function | Serine protease inhibitor. Inhibits TMPRSS7 |
| Involvement in disease | Plasminogen activator inhibitor-1 deficiency (PAI-1D) |
| Subcellular Location | Secreted |
| Protein Families | Serpin family |
| Tissue Specificity | Expressed in endothelial cells (PubMed:2430793, PubMed:3097076). Found in plasma, platelets, and hepatoma and fibrosarcoma cells. |
| Database Links |
HGNC: 8583 OMIM: 173360 KEGG: hsa:5054 STRING: 9606.ENSP00000223095 UniGene: Hs.414795 |
| Pathway |
HIF-1 signaling pathway
Hippo signaling pathway p53 signaling pathway Cellular senescence Complement and coagulation cascades AGE-RAGE signaling pathway in diabetic complications Apelin signaling pathway |
| Product Name | Recombinant Human Plasminogen activator inhibitor 1(SERPINE1),Yeast |
| Code | CSB-YP021081HU |
| Size | Pls inquiry other sizes |
| Source | Yeast |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | VHHPPSY VAHLASDFGV RVFQQVAQAS KDRNVVFSPY GVASVLAMLQ LTTGGETQQQ IQAAMGFKID DKGMAPALRH LYKELMGPWN KDEISTTDAI FVQRDLKLVQ GFMPHFFRLF RSTVKQVDFS EVERARFIIN DWVKTHTKGM ISNLLGKGAV DQLTRLVLVN ALYFNGQWKT PFPDSSTHRR LFHKSDGSTV SVPMMAQTNK FNYTEFTTPD GHYYDILELP YHGDTLSMFI AAPYEKEVPL SALTNILSAQ LISHWKGNMT RLPRLLVLPK FSLETEVDLR KPLENLGMTD MFRQFQADFT SLSDQEPLHV AQALQKVKIE VNESGTVASS STAVIVSARM APEEIIMDRP FLFVVRHNPT GTVLFMGQVM EP |
| Expression Region | 24-402 |
| Protein Description | Full Length of Mature Protein |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Human Plasminogen activator inhibitor 1(SERPINE1),E.coli |
| Code | CSB-EP021081HU |
| Size | Pls inquiry other sizes |
| Source | E.coli |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-SUMO-tagged and C-terminal Myc-tagged N-terminal His-B2M-tagged and C-terminal Myc-tagged N-terminal His-GST-tagged and C-terminal Myc-tagged N-terminal His-tagged N-terminal His-SUMO-tagged N-terminal His-B2M-tagged N-terminal His-GST-tagged N-terminal GST-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | VHHPPSY VAHLASDFGV RVFQQVAQAS KDRNVVFSPY GVASVLAMLQ LTTGGETQQQ IQAAMGFKID DKGMAPALRH LYKELMGPWN KDEISTTDAI FVQRDLKLVQ GFMPHFFRLF RSTVKQVDFS EVERARFIIN DWVKTHTKGM ISNLLGKGAV DQLTRLVLVN ALYFNGQWKT PFPDSSTHRR LFHKSDGSTV SVPMMAQTNK FNYTEFTTPD GHYYDILELP YHGDTLSMFI AAPYEKEVPL SALTNILSAQ LISHWKGNMT RLPRLLVLPK FSLETEVDLR KPLENLGMTD MFRQFQADFT SLSDQEPLHV AQALQKVKIE VNESGTVASS STAVIVSARM APEEIIMDRP FLFVVRHNPT GTVLFMGQVM EP |
| Expression Region | 24-402 |
| Protein Description | Full Length of Mature Protein |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Human Plasminogen activator inhibitor 1(SERPINE1),Baculovirus |
| Code | CSB-BP021081HU |
| Size | Pls inquiry other sizes |
| Source | Baculovirus |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | VHHPPSY VAHLASDFGV RVFQQVAQAS KDRNVVFSPY GVASVLAMLQ LTTGGETQQQ IQAAMGFKID DKGMAPALRH LYKELMGPWN KDEISTTDAI FVQRDLKLVQ GFMPHFFRLF RSTVKQVDFS EVERARFIIN DWVKTHTKGM ISNLLGKGAV DQLTRLVLVN ALYFNGQWKT PFPDSSTHRR LFHKSDGSTV SVPMMAQTNK FNYTEFTTPD GHYYDILELP YHGDTLSMFI AAPYEKEVPL SALTNILSAQ LISHWKGNMT RLPRLLVLPK FSLETEVDLR KPLENLGMTD MFRQFQADFT SLSDQEPLHV AQALQKVKIE VNESGTVASS STAVIVSARM APEEIIMDRP FLFVVRHNPT GTVLFMGQVM EP |
| Expression Region | 24-402 |
| Protein Description | Full Length of Mature Protein |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Human Plasminogen activator inhibitor 1(SERPINE1),Mammalian cell |
| Code | CSB-MP021081HU |
| Size | Pls inquiry other sizes |
| Source | Mammalian cell |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | VHHPPSY VAHLASDFGV RVFQQVAQAS KDRNVVFSPY GVASVLAMLQ LTTGGETQQQ IQAAMGFKID DKGMAPALRH LYKELMGPWN KDEISTTDAI FVQRDLKLVQ GFMPHFFRLF RSTVKQVDFS EVERARFIIN DWVKTHTKGM ISNLLGKGAV DQLTRLVLVN ALYFNGQWKT PFPDSSTHRR LFHKSDGSTV SVPMMAQTNK FNYTEFTTPD GHYYDILELP YHGDTLSMFI AAPYEKEVPL SALTNILSAQ LISHWKGNMT RLPRLLVLPK FSLETEVDLR KPLENLGMTD MFRQFQADFT SLSDQEPLHV AQALQKVKIE VNESGTVASS STAVIVSARM APEEIIMDRP FLFVVRHNPT GTVLFMGQVM EP |
| Expression Region | 24-402 |
| Protein Description | Full Length of Mature Protein |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
SERPINE1 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA11239D0Rb | SERPINE1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA11239A0Rb | SERPINE1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA11239C0Rb | SERPINE1 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA11239B0Rb | SERPINE1 Antibody, HRP conjugated | Human | ELISA |
SERPINE1 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA021081GA01HU | SERPINE1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA003699 | SERPINE1 Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA122189 | SERPINE1 Antibody | Human,Rat | ELISA,IHC |
SERPINE1 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-EP021081HU1(old:CSB-RP112394h) | Recombinant Human Plasminogen activator inhibitor 1(SERPINE1),partial | E.coli |
SERPINE1 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E07946h | Human plasminogen activator inhibitor 1,PAI-1 ELISA Kit | serum, plasma, tissue homogenates | 2.201 ng/mL |
Recombinant Human Junctional adhesion molecule B(JAM2),partial
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Heart- and neural crest derivatives-expressed protein 2(HAND2)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Keratin, type II cytoskeletal 7(KRT7)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Serum amyloid P-component(APCS)
Express system: E.coli
Species: Homo sapiens (Human)
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