SERPINE1 Antibody

Datasheet
Code CSB-PA122189
Former Code(s) CSB-PA145446,CSB-PA959378
Size US$299
Uniprot No. P05121
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA122189(SERPINE1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA122189(SERPINE1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Fusion protein of Human SERPINE1
Raised in Rabbit
Species Reactivity Human,Rat
Tested Applications ELISA,IHC;ELISA:1:1000-1:5000,IHC:1:25-1:100
Relevance This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Immunogen Species Homo sapiens (Human)
Target Names SERPINE1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Serine protease inhibitor. Inhibits TMPRSS7
Involvement in disease Plasminogen activator inhibitor-1 deficiency (PAI-1D)
Subcellular Location Secreted
Protein Families Serpin family
Tissue Specificity Expressed in endothelial cells (PubMed:2430793, PubMed:3097076). Found in plasma, platelets, and hepatoma and fibrosarcoma cells.
Database Links

HGNC: 8583

OMIM: 173360

KEGG: hsa:5054

STRING: 9606.ENSP00000223095

UniGene: Hs.414795

Pathway HIF-1 signaling pathway
Hippo signaling pathway
p53 signaling pathway
Cellular senescence
Complement and coagulation cascades
AGE-RAGE signaling pathway in diabetic complications
Apelin signaling pathway

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