SERPINE1 Antibody

Datasheet
Code CSB-PA11239A0Rb
See More Details Free Antibody trial simple
Size US$299Purchase it in Cusabio online store
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Uniprot No. P05121
Image
  • Western Blot
    Positive WB detected in: U251 whole cell lysate
    All lanes: SERPINE1 antibody at 2.5µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 46, 44 kDa
    Observed band size: 46, 44 kDa

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA11239A0Rb at dilution of 1:100

  • Immunofluorescent analysis of U251 cells using CSB-PA11239A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Immunogen Recombinant Human Plasminogen activator inhibitor 1 protein (24-398AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200
Relevance Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1), SERPINE1, PAI1 PLANH1
Immunogen Species Human
Research Area Cardiovascular
Target Names SERPINE1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Serine protease inhibitor. Inhibits TMPRSS7
Involvement in disease Plasminogen activator inhibitor-1 deficiency (PAI-1D)
Subcellular Location Secreted
Protein Families Serpin family
Tissue Specificity Expressed in endothelial cells (PubMed:2430793, PubMed:3097076). Found in plasma, platelets, and hepatoma and fibrosarcoma cells.
Database Links

HGNC: 8583

OMIM: 173360

KEGG: hsa:5054

STRING: 9606.ENSP00000223095

UniGene: Hs.414795

Pathway HIF-1 signaling pathway
Hippo signaling pathway
p53 signaling pathway
Cellular senescence
Complement and coagulation cascades
AGE-RAGE signaling pathway in diabetic complications
Apelin signaling pathway

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