Recombinant Human Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform(PPP2R2C)

Code CSB-YP897535HU
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Source Yeast
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Code CSB-EP897535HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-MP897535HU
Size Pls inquire
Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names PPP2R2C
Uniprot No. Q9Y2T4
Alternative Names 2ABG_HUMAN; B55 gamma; Gamma isoform of regulatory subunit B55 protein phosphatase 2; IMYPNO 1; IMYPNO; IMYPNO1; MGC33570; OTTHUMP00000115505; Phosphoprotein phosphatase 2A BR gamma regulatory chain; PP2A subunit B B gamma isoform; PP2A subunit B B55 gamma isoform; PP2A subunit B isoform B55-gamma; PP2A subunit B isoform gamma; PP2A subunit B isoform PR55-gamma; PP2A subunit B isoform R2-gamma; PP2A subunit B PR55 gamma isoform; PP2A subunit B R2 gamma isoform; PPP2R2C; PPP2R2C protein; PR 52; PR 55G; PR52; PR55G; Protein phosphatase 2 (formerly 2A) regulatory subunit B gamma isoform; Protein phosphatase 2 regulatory subunit B gamma; Protein phosphatase 2 regulatory subunit B gamma isoform; Protein phosphatase 2A1 B gamma subunit; Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
Species Homo sapiens (Human)
Expression Region 1-447
Target Protein Sequence MGEDTDTRKI NHSFLRDHSY VTEADIISTV EFNHTGELLA TGDKGGRVVI FQREPESKNA PHSQGEYDVY STFQSHEPEF DYLKSLEIEE KINKIKWLPQ QNAAHSLLST NDKTIKLWKI TERDKRPEGY NLKDEEGKLK DLSTVTSLQV PVLKPMDLMV EVSPRRIFAN GHTYHINSIS VNSDCETYMS ADDLRINLWH LAITDRSFNI VDIKPANMED LTEVITASEF HPHHCNLFVY SSSKGSLRLC DMRAAALCDK HSKLFEEPED PSNRSFFSEI ISSVSDVKFS HSGRYMLTRD YLTVKVWDLN MEARPIETYQ VHDYLRSKLC SLYENDCIFD KFECAWNGSD SVIMTGAYNN FFRMFDRNTK RDVTLEASRE SSKPRAVLKP RRVCVGGKRR RDDISVDSLD FTKKILHTAW HPAENIIAIA ATNNLYIFQD KVNSDMH
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Gene References into Functions
  1. B55gamma is induced by glucocorticoid receptor in human primary BM-MSCs during differentiation to osteoblast and is required for osteoblast morphogenesis. PMID: 28805158
  2. miR-572 promotes the proliferation and invasion of nasopharyngeal carcinoma by directly down-regulating PPP2R2C PMID: 28525724
  3. miR-1301 promoted prostate cancer proliferation by inhibiting PPP2R2C. PMID: 27261573
  4. These findings provide insights into mechanisms by which prostate cancers resist AR-pathway suppression and support inhibiting PPP2R2C complexes. PMID: 23493267
  5. PPP2R2C is a potential tumor suppressor gene in human brain cancers. PMID: 24126060
  6. evidence suggests that allelic variation in PPP2R2C may be associated with a variety of personality traits and ADHD per se. PMID: 22664926
  7. encoding a subunit of proteinphosphatase 2A with a unique expression pattern in brain and a role in synaptic plasticity PMID: 20601260
  8. specific PP2A complexes involved in human cell transformation PMID: 14998489
  9. novel mechanism of c-SRC regulation whereby in response to stress c-SRC activity is regulated, at least in part, through loss of the interaction with its inhibitor, PR55gamma PMID: 18069897

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Protein Families Phosphatase 2A regulatory subunit B family
Database Links

HGNC: 9306

OMIM: 605997

KEGG: hsa:5522

STRING: 9606.ENSP00000335083

UniGene: Hs.479069

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