Recombinant Human Transcription factor SOX-2 (SOX2)

Code CSB-BP022426HU
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Source Baculovirus
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Code CSB-EP022426HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-MP022426HU
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
ANOP3; cb236; Delta EF2a; lcc; MCOPS3; MGC148683; MGC2413; RGD1565646; Sex determining region Y box 2; SOX 2; Sox2; SOX2_HUMAN; SRY (sex determining region Y) box 2; SRY box containing gene 2; SRY related HMG box 2; SRY related HMG box gene 2; SRY-box 2; Transcription factor SOX 2; Transcription factor SOX-2; ysb
Homo sapiens (Human)
Expression Region
Target Protein Sequence
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Binds to the proximal enhancer region of NANOG. Critical for early embryogenesis and for embryonic stem cell pluripotency. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development.
Gene References into Functions
  1. SOX2 role in the squamous cancer progression.CCAT1 is a key target co-regulated by TP63 and SOX2 through a super-enhancer in squamous cancer cells. PMID: 30190462
  2. Results demonstrated that SOX2 is a target of miR200c in MCF7/Tax cells. Knockdown of SOX2 expression increased chemosensitivity to paclitaxel and upregulated miR200c expression in MCF7/Tax cells. PMID: 30272330
  3. BCL11A is integral to lung squamous cell carcinoma pathology and highlights the disruption of the BCL11A-SOX2 transcriptional programme as a novel candidate for drug development. PMID: 30127402
  4. Hedgehog signaling (HH) and SOX2 function are inclined to developmental cues and arbitrating malignant growth in prostate cancer. SOX2 inhibition reduces cell proliferation and induces apoptosis. Conjoint inhibition of SOX2 and HH pathway induce apoptosis, reduce proliferation and migration. PMID: 27816521
  5. The results remind us that clinical anophthalmia may be accompanied by sensorineural hearing loss and may be associated with SOX2 mutation, and it will contribute to improving diagnosis and patient care. PMID: 30262714
  6. Metastatic double primary endometrioid endometrial and ovarian carcinoma sections expressed a higher level of SOX2 compared to the corresponding DPEEOC tissues. PMID: 29569698
  7. The invasion and migration of osteosarcoma cells were down-regulated significantly through the inhibition of Sox2 by inactivating Wnt/beta-catenin signaling pathway related proteins PMID: 29619662
  8. SOX2 is a critical oncogene linked to cancer stemness properties in urothelial carcinoma of the bladder. PMID: 29180467
  9. Six SOX2 positive synovial sarcoma cases were analyzed by FISH using a SOX2/CEN3 dual color FISH probe PMID: 29773426
  10. Tumor tissue Sox2 expression was not positively correlated with histologic grade, pathological tumor size and prognosis in surgical patients with triple-negative breast cancer. PMID: 29536377
  11. Study in glioma stem-like cells (GSCs) identified SOX2 as one of downstream METTL3 targets and further recruitment of HuR onto m6A-modified sites in SOX2 is essential for SOX2 mRNA stabilization. METTL3 alters the DNA repair efficiency and radiation sensitivity partially via SOX2 in GSCs. PMID: 28991227
  12. Myeloid Zinc Finger 1 and GA Binding Protein Co-Operate with Sox2 in Regulating the Expression of Yes-Associated Protein 1 in Cancer Cells PMID: 28905448
  13. Human cytomegalovirus IE1 causes SOX2 downregulation by promoting the nuclear accumulation and inhibiting the phosphorylation of STAT3, a transcriptional activator of SOX2 expression. PMID: 29950413
  14. hypopharyngeal squamous cell carcinomas characteristically almost completely lacking SOX2 expression appeared to be aggressive neoplasms with high recurrence rates. Promoter hypermethylation was determined to be a major mechanism underlying epigenetic SOX2 silencing PMID: 29143365
  15. this study shows that basaloid squamous cell carcinoma and basal cell carcinoma of the head and neck can be readily distinguished by a limited panel consisting primarily of EMA, and supported by SOX2 and p16 PMID: 27438511
  16. Results show that the levels of small nucleolar RNA host gene 5 (SNHG5) and SRY (sex determining region Y)-box 2 protein (SOX2) were significantly downregulated in osteoarthritis (OA) tissues, while the level of miR-26a was upregulated. PMID: 29409014
  17. SOX2 copy number increases are detectable in a substantial proportion of high-grade HPV-positive vulvar carcinomas with basaloid differentiation. PMID: 28700423
  18. The staining patterns did not reliably distinguish cervical intraepithelial neoplasia, grade 3 (CIN 3) from CIN 3-like Squamous cell carcinoma (SCC). Small infiltrative tumor nests around the margins of CIN 3 or deeply invasive CIN 3-like SCC often showed a localized reduction in SOX2 expression suggesting SOX2 downregulation during the transition to invasive growth. PMID: 28319578
  19. Low SOX2 expression marks a distinct subset of adenoid cystic carcinoma of the head and neck and is associated with an advanced tumor stage PMID: 29596469
  20. SOX2 overexpression in DPSCs promoted the regulation of odontoblast differentiation of DPSCs PMID: 29039570
  21. SOX2 expression is dependent on contact with enhancers 700 kb downstream via CTCFdependent chromatin looping. PMID: 29091765
  22. LncRNA SOX2-OT is a novel prognostic biomarker for osteosarcoma patients, it regulates osteosarcoma cells proliferation and motility through SOX2 modulation, and is correlated with patients' survival. PMID: 28960757
  23. SOX2 overexpression is associated with cancer. PMID: 29587142
  24. Histone acetyltransferase EP300 is necessary for the transcription factor SOX2 activity in basal cells, including for induction of the squamous fate. EP300 copy number gains are common in squamous cell carcinoma SQCCs, including lung cancer SQCC cell lines. PMID: 28794006
  25. NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ ALDH1A1 axis in lung adenocarcinoma. PMID: 28737489
  26. Block the activation of the VRK1 promoter by Sox2. PMID: 27334688
  27. Heterozygous loss-of-function mutations in SOX2 are the commonest cause of severe microphthalmia and anophthalmia. PMID: 28635421
  28. This data demonstrated immunogenicity of SOX2, which is specifically overexpressed on pediatric glial tumor cells. PMID: 28620836
  29. OCT4 and SOX2 work as transcriptional activators in reprogramming human fibroblasts. PMID: 28813671
  30. Sox2-expressing cells mark a subpopulation of tumor cells that fuel the growth of established BCa. SOX2-positive cells also expressed other previously reported BCa CSC markers, including Keratin14 (KRT14) and CD44v6. Ablation of Sox2-expressing cells within primary invasive BCa led to enhanced tumor regression PMID: 28793245
  31. studies on the role of SOX2 in breast cancer may provide effective biomarkers and potential therapeutic targets for the diagnosis and treatment of breast cancer PMID: 28674712
  32. In conclusion, targeted sequencing for SOX2 and VSX2 identified the etiology in two patients (7.4%) and this is the first report of SOX2 mutation from Egypt. PMID: 28121235
  33. Kat2b are essential to the differentiation through enhancing recruitment neuroectodermal factors Sox2 and Pax6 to their target sites. PMID: 28475175
  34. combined administration of small-interfering RNA (siRNA) transfection with PPARgamma ligands induced downregulation of SOX2 and MMP2 activity together with inhibition of sphere-forming activity regardless of poly(ADP-ribose) polymerase (PARP) cleavage. Taken together, our findings suggest that a combination therapy using PPARgamma ligands and its inhibitor could be a potential therapeutic strategy targeting glioblastom... PMID: 28642874
  35. DDX53 directly regulates the SOX-2 expression in drug-resistant melanoma cells. PMID: 28535666
  36. Rectal tumor tissue OCT4 (p<0.001), SOX2 (p=0.003), and NANOG (p<0.001) expressions were higher than those in adjacent tissue. PMID: 29214774
  37. Thus, SOX2 is a master regulator of the acinar cell lineage essential to the establishment of a functional organ. PMID: 28623666
  38. Results provide evidence that SOX2 expression is regulated by the transcription factor HSF1. PMID: 29316077
  39. SOX2 overexpression and the loss of Rb1 protein expression might have a pivotal role in the divergent differentiation of pluripotent embryonic-like epithelial cells and the development of esophageal small-cell carcinoma. PMID: 28106103
  40. In SOX2-deficient cells, BMP signaling is inhibited, but NODAL signaling is not activated. Thus, SOX2 appears to be downstream of BMP signaling but upstream of NODAL activation. PMID: 27283990
  41. Results show lower SOX2 in the lymph node metastases from head and neck squamous cell carcinomas (HNSCCs) and in cervical cancer of unknown primary patients compared with the primary tumor. Tumors from N1 to N3 stage exhibit decreasing SOX2 expression in the lymphatic metastases. Its expression is showed to be involved in the proliferation and migration of HNSCC cell lines. PMID: 28002801
  42. SOX2 overexpression could be used as a positive prognostic factor in patients with stage III lung squamous cell carcinoma receiving adjuvant radiotherapy PMID: 26323639
  43. The survival rate was increased by 11.1% in Oct4/Sox2-hAT-MSC-injected mice. PMID: 28438862
  44. hypoxia-NOTCH1-SOX2 signaling axis is important for activation of ovarian cancer stem cells. PMID: 27489349
  45. This severe movement disorder appears to be a feature of some types of SOX2-anophthalmia syndrome thus expanding the phenotype. We strongly recommend that all newborns with bilateral anophthalmia/microphthalmia be screened for mutations in SOX2 PMID: 27427475
  46. Findings indicate that long-term exposure to IM results in dysregulation of stem cell renewal-regulatory Hippo (MST1/2)/YAP signaling, and that inhibition of miR-181a using a microRNA sponge inhibitor resulted in decreased transcription of SOX2 and SALL4. PMID: 28103766
  47. The authors found that high/positive SOX2 alterations, either DNA amplification or protein expression, were favorable for overall survival (OS) in non-small cell lung cancer. On the contrary, high/positive Nestin protein expression was poor for OS. PMID: 27150062
  48. Data show that tunicamycin reduces the expression of self-renewal regulator Sox2 at translation level. PMID: 27119230
  49. Increasing SOX2 reduces growth inhibition mediated by MEK and AKT inhibitors; whereas knockdown of SOX2 further reduces growth when Pancreatic ductal adenocarcinoma cells are treated with these inhibitors. Thus, targeting SOX2, or its mode of action, could improve the treatment of Pancreatic ductal adenocarcinoma. PMID: 27145457
  50. This study discloses novel SOX2 target genes driving neuroendocrine differentiation and spread of PC and proposes SOX2 as a functional biomarker of LN metastasization for prostate cancer. PMID: 26540632

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Involvement in disease
Microphthalmia, syndromic, 3 (MCOPS3)
Subcellular Location
Database Links

HGNC: 11195

OMIM: 184429

KEGG: hsa:6657

STRING: 9606.ENSP00000323588

UniGene: Hs.518438

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