Recombinant Human Transforming growth factor beta-3(TGFB3),partial

Code CSB-YP023449HU
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Source Yeast
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Code CSB-EP023449HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP023449HU
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Source Baculovirus
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Code CSB-MP023449HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names TGFB3
Uniprot No. P10600
Alternative Names ARVD; ARVD1; FLJ16571; LDS5; MGC105479; MGC118722; prepro-transforming growth factor beta-3; RNHF; TGF beta 3; TGF beta3; TGF-beta-3; TGFB 3; Tgfb3; TGFB3_HUMAN; transforming growth factor beta 3; Transforming growth factor beta-3
Species Homo sapiens (Human)
Expression Region 24-300
Target Protein Sequence LSTCTTL DFGHIKKKRV EAIRGQILSK LRLTSPPEPT VMTHVPYQVL ALYNSTRELL EEMHGEREEG CTQENTESEY YAKEIHKFDM IQGLAEHNEL AVCPKGITSK VFRFNVSSVE KNRTNLFRAE FRVLRVPNPS SKRNEQRIEL FQILRPDEHI AKQRYIGGKN LPTRGTAEWL SFDVTDTVRE WLLRRESNLG LEISIHCPCH TFQPNGDILE NIHEVMEIKF KGVDNEDDHG RGDLGRLKKQ KDHHNPHLIL MMIPPHRLDN PGQGGQRKKR
Protein Length partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Involved in embryogenesis and cell differentiation.
Gene References into Functions
  1. Elevations of TGF-beta3, SMAD2 and SMAD4 in hypertrophic scars and increase of IGF-1R in immature stages may give some clues for acne hypertrophic scar formation. PMID: 30167815
  2. This review highlights advances in the understanding of the cellular sources, activation processes, contextual determinants, and immunological roles of TGF-beta3 with comparisons to other TGF-beta isoforms. PMID: 30071700
  3. This study showed that YOD1 overexpression enhances cell migration by promoting TGF-beta3 signaling which may play an important role in lip and palate formation. PMID: 30145984
  4. We suggest that increased TGFbeta3 levels are responsible for development of aggressive prostate cancer in African American patients as a consequence of development of resistance to inhibitory effects of TGFbeta on cell proliferation and induction of invasive metastatic behavior PMID: 29474521
  5. data implies that miR-140 is a potent chondrogenic differentiation inducer for iPSCs and also, we have showed increasing chondrogenic differentiation by using overexpression of miR-140 and TGFbeta3. PMID: 29456027
  6. The increase in TGF-beta3 found in inflammatory wound healing (WF) highlights its negative effect on wound healing, while the increased levels of sEng in granulating WF affects the leukocyte adhesion/transmigration through the endothelium, reducing the inflammatory response and favoring the wound healing. PMID: 29065449
  7. In nonsyndromic CL+/-P Malay patients,the prevalence of the mutations in the TGFbeta3 gene was 17.7%. For the TGFbeta3 gene, there was no mutation in the coding region in either of the groups. PMID: 26151095
  8. Human dental apical papilla-derived Mesenchymal stem cells (hSCAPs) can produce and secrete TGFbeta3 in response to micro-environmental cues. PMID: 25690385
  9. Higher TGF-beta3 serum concentrations are a risk factor for uterine fibroids. PMID: 27743697
  10. High expression of TGF-beta3 in preeclampsia decidua stimulates miR-494 in decidual mesenchymal stem cells (MSC) and attenuates the regulation of MSC switching the macrophage toward M2 type, contributing to an immune imbalance at maternal-fetal interface. PMID: 27149081
  11. The frequency GA genotype of transforming growth factor beta 3 (TGFbeta3) gene was associated with increased risk of non-syndromic cleft palate only (NS CPO). PMID: 28364787
  12. combining TGF-beta3 with BMP-2 was able to promote the process of bone formation more markedly in vitro, providing a promising clinical strategy in the field of skeletal regeneration and in fracture healing. PMID: 27878265
  13. No significant association was observed in MMP13, TIMP2 and TGFB3 genes with CP or PI. CP is a risk factor to develop PI, however, there is no association of both diseases with polymorphisms in the MMP13, TIMP2 and TGFB3 genes PMID: 27058373
  14. Our study showed that TGFA/TGFB3/MSX1 gene polymorphisms were associated with congenital NSHI. CCGTAC and TTACGT haplotypes might be protective factors, while TTGCGC haplotype might be a risk factor for congenital NSHI. TGFA/TGFB3/MSX1 gene rs3771494, rs1058213, rs3917201, rs2268626, rs3821949, and rs62636562 haplotype analysis showed that haplotype CCGTAC and TTACGT might be protective factors (both P<0.001) PMID: 27356075
  15. increased stromal POSTN induced by TGF-beta3 directly accelerated the growth, migration and invasion of cancer cells PMID: 26857387
  16. Taken together, these results demonstrate that insulin and TGF-beta3 present antagonistic effects during the chondrogenesis of human bone marrow-derived stem/progenitor cells. PMID: 26866713
  17. CCN4 has a positive influence on chondrogenic differentiation by modulating the effects of TGF-beta3. PMID: 26555637
  18. TGFB3 polymorphism is associated with male infertility. PMID: 26612435
  19. Results identified a novel human TGFB3 mutation, which contributes to the clinical delineation of the emerging connective tissue disorder tentatively called Rienhoff syndrome, a disorder overlapping with Marfan and Loeys-Dietz syndrome. PMID: 26184463
  20. Fluocinolone Acetonide enhances TGF-beta3-associated chondrogenesis of bone marrow derived mesenchymal stem cells PMID: 25753754
  21. TGF-beta3-expressing CD4+CD25(-)LAG3+ regulatory T cells have a role in controlling humoral immune responses PMID: 25695838
  22. TGF-beta3 mediates the attenuating effect of MSCs on both the proliferation and extracellular matrix production of human keloid fibroblasts and decreases skin fibrosis PMID: 25858630
  23. TGF-beta3 existed in synovium and LBs of SC, and was responsible for the pathogenesis of SC. PMID: 25742744
  24. TGFB3 polymorphism, significant differences were observed for allele and genotype frequencies between caries free and caries affected individuals in oral cleft group (p = 0.013 and 0.006 for allele and genotype frequencies respectively). PMID: 25307808
  25. TGF-beta3 may contribute to the persistent intestinal dysfunction seen in gastroschisis-related intestinal dysfunction. PMID: 25431043
  26. Data indicate greater staining for transforming growth factor beta 3 (TGF-beta3) in healthier tissue compared with diseased menisci. PMID: 25418724
  27. The results show an intricate interplay between p53 and TGF-beta3 whereby p53 inhibits the TGF-beta3-induced expression of genes, e.g., EPHB2, to impede tumor cell invasion and migration PMID: 25257729
  28. findings emphasize the broad clinical variability associated with TGFB3 mutations and highlight the importance of early recognition of the disease because of high cardiovascular risk PMID: 25835445
  29. It was found that the majority of TGF-beta3 that was loaded onto the scaffold was released in a controlled manner over the first 10days of culture, with comparable long-term chondrogenesis PMID: 24907658
  30. We identified genetic variants in TGFB3 and ARHGAP29 associated with suboptimal healing outcome. PMID: 24635173
  31. These results unequivocally demonstrate that human TGF-beta3 elicits bone induction by up-regulation of endogenous BMP-2 and is blocked by hNoggin. PMID: 24438909
  32. TGF-beta3 could be stably expressed in pcDNA3.1(+)-hTGF-beta3-transfected PSCs. PMID: 21823016
  33. Liarozole decreased TGF-beta3 and TGF-beta3-mediated extracellular matrix expression in a 3D uterine leiomyoma culture system. PMID: 24825427
  34. meta-analysis suggests that TGF-beta3 gene polymorphisms may contribute to NSCLP susceptibility, especially among Asian populations. PMID: 24053560
  35. Allelic and haplotypic associations implicate a possible role of TGFB3 in nonsyndromic cleft lip with or without cleft palate in the Chilean population. PMID: 20170386
  36. This study provides a comprehensive list of genes differentially expressed in the healing corneal epithelial cells of diabetic corneas and suggests the therapeutic potential of TGF-beta3 for treating corneal and skin wounds in diabetic patients. PMID: 24306208
  37. The GG genotype and G allele of TGF-beta 3 were significantly different in the patient group compared with the control. PMID: 23023602
  38. Shear stress of vascular endothelial cells induces TGF-beta3 signaling and subsequent activation of Kruppel-like factor 2 and NO, and represents a novel role for TGF-beta3 in the maintenance of homeostasis in a hemodynamic environment. PMID: 23968981
  39. Mutation in TGFB3 is associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome. PMID: 23824657
  40. These findings suggest human serum, FGF-2 and TGF-beta3 as possible candidates to support biological treatment strategies of AF defects. PMID: 23122986
  41. These results highlight TGFbeta/5-HT signaling as a potent mechanism for control of biomechanical remodeling of atrioventricular cushions during development. PMID: 22880017
  42. Hypoxia may inhibit the invasion of human extravillous trophoblast cells through inducing the integrin switch from alpha1 integrin to alpha5 integrin and promoting TGFB3 expression. PMID: 22674391
  43. IL-1B & TGFB3 synergistically activated MMP)-1, MMP-3,& MMP-10 gene expression in NSCLC cells via MAPK-dependent pathways. PMID: 22796605
  44. Significant statistical differences were found for genotype frequencies between tooth agenesis and TGFB3 control samples, as well as for allele and genotype frequencies between unilateral tooth agenesis and TGFB3 control samples. PMID: 22191848
  45. TGF-beta3 isoform is a key agent in seminal plasma that signals induction of proinflammatory cytokine synthesis in cervical cells. PMID: 22706080
  46. analysis of genetic variants hints at the contribution of TGFB3 and MN1 in the aetiology of submucous cleft palate PMID: 22409215
  47. involved in the modulation of epithelial barrier function by regulating assembly of tight junctions PMID: 22369552
  48. This study confirms the crucial role of TGF-beta3 in the fusion of palatal shelves during development and further, provides novel evidence of TGF-beta3 gene polymorphism in the etiology of nonsyndromic cleft lip and palate in Indian subpopulation PMID: 22143699
  49. We observed significant downregulation of Transforming Growth Factor beta 3 in women with recurrent miscarriage compared with controls. PMID: 22266274
  50. study suggests that both combination medium, but better with the addition of TGF-ss3 could enhance BMSCs chondrogenesis in vivo, and promotes themaintenance of the chondrocyte phenotype PMID: 21666950
  51. TGF-beta, besides acting as an inhibitor, also can, by dampening the noggin-mediated negative-feedback loop, enhance BMP-induced osteoblast differentiation. PMID: 21611961
  52. TGF-beta3 may regulate taste epithelial cell homeostasis through controlling cell proliferation. PMID: 19787410
  53. Mesenchymal stem cells and bone marrow-derived mononuclear cells can generate tendon-like tissue in 7 days mediated by transforming growth factor beta3. PMID: 20736064
  54. The restoration of the expression of TbetaRII and TbetaRIII in oral cancerous tissues may represent a novel strategy for the treatment of oral carcinoma. PMID: 21352603
  55. These results provide evidence that the two TbetaRI:TbetaRII heterodimers bind and mediate TGF-beta3 signalling. PMID: 21423151
  56. MSX1 and TGF-beta3 are direct targets of FOXE1. PMID: 21177256
  57. Leiomyoma-secreted TGF-beta3 induces bone morphogenetic protein 2 resistance in endometrium by down-regulation of bone morphogenetic protein receptor 2, likely causing defective endometrial decidualization PMID: 21084396
  58. A susceptibility locus was identified on chromosome 14q24.3-31.2. The candidate functional gene is TGFB3. A suggestive linkage for mandibular prognathism in a Han Chinese pedigree. PMID: 21041550
  59. TGF-B3 was upregulated in early and late osteogenesis in microarray and qRT analyses and demonstrated the largest increase in expression when compared with day 1. PMID: 20613589
  60. CYR61 and NOV are regulated by HIF-1alpha and TGF-beta3 in the trophoblast cell line JEG3, and their enhanced secretion could be implicated in appropriate placental invasion. PMID: 20237132
  61. TGF-beta3 induced a molecular phenotype in myometrial cells that was similar to leiomyoma cells, with elevated production of extracellular matrix (ECM)-related genes and decreased production of ECM degradation-related genes. PMID: 19328471
  62. Aberrant production of excessive and disorganized extracellular matrix in uterine leiomyoma involves the activation of the TGF-beta3 signaling pathway and excessive production of GAG-rich versican variants. PMID: 19700613
  63. Studies indicate that TNFalpha and TGFbeta3 are present at high levels in the microenvironment of the seminiferous epithelium during spermatogenesis. PMID: 19651533
  64. Studies indicated that TGF-beta3 may actually play a protective role against tumourigenesis in a range of tissues including the skin, breast, oral and gastric mucosa. PMID: 19656717
  65. crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex PMID: 11850637
  66. downregulation of TGF-beta 3 expression found in pre-eclamptic umbilical cord may contribute to the abnormal structure and mechanical properties seen in these pathological umbilical cords PMID: 11969342
  67. TGFbeta3 may have a role in mediating progesterone- and progestogen-induced endometrial differentiation PMID: 12168782
  68. TGFbeta3 regulates GM-CSF induced human myelopoiesis PMID: 12171249
  69. determination of the importance of conformational entropy in the interaction of TGF-beta3 with the receptors PMID: 12221089
  70. TGF-beta3 expression in peritoneal fibroblasts was not affected by hypoxia or TGF-beta1 stimulation PMID: 12607775
  71. mutations make a contribution to clefts in South American populations PMID: 12651933
  72. positively associated with cleft lip and/or palate with hypodontia outside the cleft region PMID: 12733956
  73. NMR analysis of the extracellular domain of the human TGFbeta type II receptor in complex with monomeric TGFbeta3 PMID: 15017149
  74. regulation of TGF-beta3 promoter activity by HIF-1 represents a mechanism for trophoblast differentiation during hypoxia. PMID: 15155569
  75. We identified TGFbeta3 as the disease gene involved in ARVD1. PMID: 15639475
  76. No association was found between TGF-beta3 gene polymorphisms essential hypertension in Chinese. PMID: 15924806
  77. TGF-beta 3 may promote endometrial tissue repair through the inhibition of the proliferation, expansion, and migration of endometrial stromal cells, and through stimulation of contraction of the collagen gel matrix by these cells. PMID: 16210002
  78. Depletion of TGFbeta3 from serum converts serum to a plasmalike reagent. PMID: 16549496
  79. Hunchback sequence binding protein may function as a TGF-beta3 gene transcriptional regulator and may be expressed in a cell type-specific manner. PMID: 16781676
  80. CD24 regulates E-cadherin and TGF-beta3 expression in cultured oral epithelial cells PMID: 16930538
  81. Altered crosstalk between RA, GABAergic, and TGF-beta signaling systems could be involved in human cleft palate fibroblast phenotype. PMID: 17225872
  82. TGF-beta3 may play a role as regulator of variety of cellular events during HELLP syndrome. High local expression may be responsible for remodeling of the placental structure resulting in dysfunction of maternal-fetal circulation. PMID: 17671384
  83. collagen I induces EMT in lung cancer cells by activating autocrine TGF-beta3 signaling. Epidermal growth factor also seems to initiate EMT via a TGF-dependent mechanism. PMID: 17673689
  84. There is a significantly elevated concentration of TGF-beta3 in PE eyes PMID: 18049952
  85. TGF-beta 3 is closely related to mineral maturation matrix in human developing teeth PMID: 18078367
  86. TGF-beta 3 was detected from the canalisation stage of the salivary gland, being weakly expressed on ductal cells, and it was the only factor detected on myoepithelial cells. PMID: 18080134
  87. oxygen regulates the placental expression of endoglin via TGF-beta 3 PMID: 18156205
  88. TGF-beta complexes assemble cooperatively through recruitment of the low-affinity (type I) receptor by the ligand-bound high-affinity (type II) pair. PMID: 18243111
  89. Data support the involvement of TGFB3 in the development of oral clefts in patients among 204 triads of central European origin. PMID: 18480962
  90. Snail and Slug promote formation of beta-catenin-T-cell factor (TCF)-4 transcription complexes that bind to the promoter of the TGF-beta3 gene to increase its transcription. PMID: 18799618
  91. BMP-2 enhances TGF-beta3-mediated chondrogenesis of mesenchymal stromal cells. PMID: 18950289
  92. the combination of daily loading and TGFbeta(3) administration produced superior osteocyte survival at the core centres when compared to loading or TGFbeta alone. PMID: 19107876
  93. Overexpression of TGF-beta3 and extracellular matrix proteins may represent antecedent tissue repair and therefore may be considered a significant event in the resolution of acquired reactive perforating collagenosis lesions PMID: 19231643
  94. 6 breast cancer studies show a negative correlation between TGF-beta3 mRNA levels & increasing tumor grade. High expression of TGF-beta3 mRNA is associated with good outcomem suggesting a protective role. Review. PMID: 19396528
  95. A fetal TGF-beta3 polymorphism (rs1146414) is associated with pregnancy-induced hypertension in a predominantly Hispanic population. PMID: 19628198

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Involvement in disease Arrhythmogenic right ventricular dysplasia, familial, 1 (ARVD1); Loeys-Dietz syndrome 5 (LDS5)
Subcellular Location Secreted
Protein Families TGF-beta family
Database Links

HGNC: 11769

OMIM: 107970

KEGG: hsa:7043

STRING: 9606.ENSP00000238682

UniGene: Hs.592317

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