Recombinant Mouse Adenylate cyclase type 1(Adcy1) ,partial

Code CSB-YP001336MO
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Source Yeast
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Code CSB-EP001336MO
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Source E.coli
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Code CSB-EP001336MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP001336MO
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Source Baculovirus
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Code CSB-MP001336MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Adcy1
Uniprot No. O88444
Alternative Names Adcy1Adenylate cyclase type 1; EC 4.6.1.1; ATP pyrophosphate-lyase 1; Adenylate cyclase type I; Adenylyl cyclase 1; Ca(2+)/calmodulin-activated adenylyl cyclase
Species Mus musculus (Mouse)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels
Gene References into Functions
  1. Data show in fragile X mental retardation syndrome 1 protein (Fmr1) knockout neurons, type 1 adenylyl cyclase (Adcy1) mRNA translation is enhanced, leading to excessive production of ADCY1 protein and insensitivity to neuronal stimulation. PMID: 28218269
  2. data indicate that ST034307 is a selective small-molecule inhibitor of AC1 and suggest that selective AC1 inhibitors may be useful for managing pain. PMID: 28223412
  3. Genetic deletion of AC8 (adenylyl cyclase 8) but not AC1 abolished long-lasting anxiety. PMID: 27234425
  4. Following ethanol administration, phosphorylation of TrkB is significantly increased in the striatum of Adcyl1 and Adcyl6 knock-out mice. PMID: 26992697
  5. Findings provide evidence to link activation of alpha7 nAChRs to a cAMP rise via AC1, which defines a new signaling pathway employed by alpha7 nAChRs PMID: 25937212
  6. Results indicate that thalamic AC1 plays a major role in patterning and refinement of the mouse thalamocortical circuitry PMID: 25644422
  7. Results demonstrate that ADCY1 has an evolutionarily conserved role in hearing. PMID: 24482543
  8. Data indicate that genetic ablation of RGS6 expression resulted in anxiolytic and antidepressant behavior by enhancing signaling through the 5-HT1A receptor-adenylyl cyclase (AC) axis. PMID: 24421401
  9. Contrast sensitivity is similarly reduced in Adcy1-/- mice. PMID: 24048828
  10. These results suggest that AC1 in retinal ganglion cell axons mediates the development of retinotopy and eye-specific segregation in the superior colliculus and dorsal lateral geniculate nucleus. PMID: 22102330
  11. The lower cAMP and AC mRNA level in hippocampus might participate in the molecular pathogenesis of ischemia/ reperfusion. PMID: 21162195
  12. Data demonstrate that stimulating the dopamine Dreceptor is essential in maintaining the normal rhythmic production of adenylyl cyclase 1 from transcript to enzyme activity. PMID: 21676039
  13. we have identified Adcy1 as a novel podocyte signaling protein that seems to have a role in compensatory physiological processes in the glomerulus. PMID: 21196775
  14. These results suggest a function of adenylate cyclase 1 in the formation of peripheral nerve trajectories such as branching and pruning PMID: 20692345
  15. AC1 has an essential role in fine patterning of the retinal map; retinal fibers from the ipsilateral and contralateral eye fail to segregate into eye-specific domains in the lateral geniculate nucleus and superior colliculus in AC1 mutant barrelless mice PMID: 12657682
  16. The potential role of AC1 in mediating synaptic plasticity and regulating AMPAR trafficking during barrel map development is studied using barrelless mice, mutants without AC1 activity or cortical 'barrel' maps. PMID: 12897788
  17. AC1 gene expression begins early in embryonic life (before E13), and its expression is much more widespread than in adults. PMID: 15844169
  18. A presynaptic, cell autonomous role of AC1 is demonstrated in the retina; AC1 is necessary to enact a retraction response of the retinal axons to ephrin-A5 during refinement of the retinotopic map. PMID: 16421306
  19. AC1 plays an important role in neuronal excitotoxicity PMID: 17121841
  20. AC1 protein increased in hippocampus from postnatal days 7-14. By adulthood, abundant AC1 protein expression was observed in the mossy fiber tract in hippocampus and the molecular layer of cerebellum, with diffuse expression in the cortex, thalamus. PMID: 17335981
  21. data suggest that AC1/AC8 are crucial activators of cell survival signaling pathways acutely following ethanol exposure and represent molecular factors that may directly modulate the severity of symptoms associated with Fetal Alcohol Syndrome PMID: 18992344
  22. Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles. PMID: 19029295
  23. These data illustrate that calcium coupling to cAMP contributes to the stability of remote memory and identifies AC1 as a potential drug target site to improve long-term remote memory. PMID: 19036980
  24. The decrease in divalent calcium ion (Ca2+)-stimulated adenylyl cyclase activity during aging of wild-type mice may be an adaptive mechanism required to maintain spatial memory function. PMID: 19726641

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Subcellular Location Membrane, Multi-pass membrane protein, Cell membrane, Multi-pass membrane protein, Cytoplasm, Membrane raft
Protein Families Adenylyl cyclase class-4/guanylyl cyclase family
Tissue Specificity Expressed throughout inner ear development.
Database Links

KEGG: mmu:432530

STRING: 10090.ENSMUSP00000020706

UniGene: Mm.259733

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