Recombinant Mouse Adenylate cyclase type 1 (Adcy1), partial

1. Data show in fragile X mental retardation syndrome 1 protein (Fmr1) knockout neurons, type 1 adenylyl cyclase (Adcy1) mRNA translation is enhanced, leading to excessive production of ADCY1 protein and insensitivity to neuronal stimulation. PMID: 28218269
2. data indicate that ST034307 is a selective small-molecule inhibitor of AC1 and suggest that selective AC1 inhibitors may be useful for managing pain. PMID: 28223412
3. Genetic deletion of AC8 (adenylyl cyclase 8) but not AC1 abolished long-lasting anxiety. PMID: 27234425
4. Following ethanol administration, phosphorylation of TrkB is significantly increased in the striatum of Adcyl1 and Adcyl6 knock-out mice. PMID: 26992697
5. Findings provide evidence to link activation of alpha7 nAChRs to a cAMP rise via AC1, which defines a new signaling pathway employed by alpha7 nAChRs PMID: 25937212
6. Results indicate that thalamic AC1 plays a major role in patterning and refinement of the mouse thalamocortical circuitry PMID: 25644422
7. Results demonstrate that ADCY1 has an evolutionarily conserved role in hearing. PMID: 24482543
8. Data indicate that genetic ablation of RGS6 expression resulted in anxiolytic and antidepressant behavior by enhancing signaling through the 5-HT1A receptor-adenylyl cyclase (AC) axis. PMID: 24421401
9. Contrast sensitivity is similarly reduced in Adcy1-/- mice. PMID: 24048828
10. These results suggest that AC1 in retinal ganglion cell axons mediates the development of retinotopy and eye-specific segregation in the superior colliculus and dorsal lateral geniculate nucleus. PMID: 22102330
11. The lower cAMP and AC mRNA level in hippocampus might participate in the molecular pathogenesis of ischemia/ reperfusion. PMID: 21162195
12. Data demonstrate that stimulating the dopamine Dreceptor is essential in maintaining the normal rhythmic production of adenylyl cyclase 1 from transcript to enzyme activity. PMID: 21676039
13. we have identified Adcy1 as a novel podocyte signaling protein that seems to have a role in compensatory physiological processes in the glomerulus. PMID: 21196775
14. These results suggest a function of adenylate cyclase 1 in the formation of peripheral nerve trajectories such as branching and pruning PMID: 20692345
15. AC1 has an essential role in fine patterning of the retinal map; retinal fibers from the ipsilateral and contralateral eye fail to segregate into eye-specific domains in the lateral geniculate nucleus and superior colliculus in AC1 mutant barrelless mice PMID: 12657682
16. The potential role of AC1 in mediating synaptic plasticity and regulating AMPAR trafficking during barrel map development is studied using barrelless mice, mutants without AC1 activity or cortical 'barrel' maps. PMID: 12897788
17. AC1 gene expression begins early in embryonic life (before E13), and its expression is much more widespread than in adults. PMID: 15844169
18. A presynaptic, cell autonomous role of AC1 is demonstrated in the retina; AC1 is necessary to enact a retraction response of the retinal axons to ephrin-A5 during refinement of the retinotopic map. PMID: 16421306
19. AC1 plays an important role in neuronal excitotoxicity PMID: 17121841
20. AC1 protein increased in hippocampus from postnatal days 7-14. By adulthood, abundant AC1 protein expression was observed in the mossy fiber tract in hippocampus and the molecular layer of cerebellum, with diffuse expression in the cortex, thalamus. PMID: 17335981
21. data suggest that AC1/AC8 are crucial activators of cell survival signaling pathways acutely following ethanol exposure and represent molecular factors that may directly modulate the severity of symptoms associated with Fetal Alcohol Syndrome PMID: 18992344
22. Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles. PMID: 19029295
23. These data illustrate that calcium coupling to cAMP contributes to the stability of remote memory and identifies AC1 as a potential drug target site to improve long-term remote memory. PMID: 19036980
24. The decrease in divalent calcium ion (Ca2+)-stimulated adenylyl cyclase activity during aging of wild-type mice may be an adaptive mechanism required to maintain spatial memory function. PMID: 19726641

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KEGG: mmu:432530

STRING: 10090.ENSMUSP00000020706

UniGene: Mm.259733