Recombinant Mouse Adenylate cyclase type 3(Adcy3) ,partial

Code CSB-YP840868MO
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Source Yeast
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Code CSB-EP840868MO
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Source E.coli
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Code CSB-EP840868MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP840868MO
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Source Baculovirus
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Code CSB-MP840868MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Adcy3
Uniprot No. Q8VHH7
Alternative Names Adcy3; Adenylate cyclase type 3; EC 4.6.1.1; ATP pyrophosphate-lyase 3; Adenylate cyclase type III; AC-III; Adenylate cyclase; olfactive type; Adenylyl cyclase 3; AC3
Species Mus musculus (Mouse)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling
Gene References into Functions
  1. Cell apoptosis in the testicular tissues of AC3(-/-) mice increased significantly compared with that in wild-type (AC3(+/+)) mice. The expression of 693 genes was altered in the testicular tissues of AC3(-/-) mice, including 330 up-regulated and 363 down-regulated gene expression, helping to elucidate the mechanisms underlying the sterility in AC3(-/-) male mice. PMID: 27864010
  2. AC3 may play a role in proximal olfactory signaling and play a role in the regulation of differentially expressed genes in mouse MOE. PMID: 26633363
  3. genetic ablation of adenylate cyclase III has drastic, location-dependent effects on cilia architecture in the mouse nose PMID: 26942602
  4. Data showed the presence mRNA of obligated downstream components of olfactory receptor signaling adenylyl cyclase 3 and olfactory G protein in the cerebral cortex of the mouse. PMID: 23817016
  5. increased Adcy3 activity robustly protect animals from diet-induced metabolic derangements PMID: 25329148
  6. Coexpression of serotonin receptor 5HT6 with adenylyl cyclase type III normalizes cilia structure and restores dendrite outgrowth. PMID: 23392690
  7. Data suggest that while ADCY3 is responsible for a share of the cAMP in osteoclasts, the reduction of cAMP levels in the absence of this gene is insufficient to augment differentiation or effect changes in bone mass in vivo. PMID: 22985540
  8. We conclude that AC3 in the main olfactory epithelium is required for detecting the mechanical force of airflow, which in turn may regulate odorant perception during sniffing. PMID: 23136416
  9. In primary culture and in situ in G93A SOD1 mice there is a large reduction in the proportion of motor neurons bearing a primary cilium. PMID: 21767396
  10. Maternal behavior was impaired in female mice deficient in adenylyl cyclase 3. PMID: 21150908
  11. AC3(-/-) mice show no short-term memory for novel objects and fail to exhibit extinction of contextual fear conditioning PMID: 21490195
  12. GSK3beta inactivation or deletion reduces aquaporin 2 expression by modulating adenylate cyclase activity and cAMP generation, thereby impairing responses to vasopressin in the renal collecting duct PMID: 20056751
  13. cAMP signals generated by AC3 in the hypothalamus may play a critical role in regulation of body weight PMID: 19750222
  14. adenylyl cyclase 3 is functional in rodent oocytes and its activity is involved in the control of oocyte meiotic arrest PMID: 12798295
  15. required for normal spermatid or spermatozoa function and male fertility PMID: 15705663
  16. point to a major role played by a crucial element of the odorant-induced transduction cascade, adenylyl cyclase 3, in the targeting of olfactory sensory neuron axons towards the brain PMID: 17537788
  17. There was robust Adcy3 expression in both olfactory sensory neuron cilia and axons during the period of active glomerular formation in neonatal transgenic mice. PMID: 17581954

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Subcellular Location Cell membrane, Multi-pass membrane protein, Cell projection, cilium, Golgi apparatus, Cytoplasm
Protein Families Adenylyl cyclase class-4/guanylyl cyclase family
Tissue Specificity Detected in the acrosomal region of epididymal spermatozoa, the acrosomal region of round spermatids and in elongating spermatids (PubMed:15705663). Detected in cilia in the olfactory epithelium (at protein level) (PubMed:9768837, PubMed:11055432, PubMed:
Database Links

KEGG: mmu:104111

STRING: 10090.ENSMUSP00000020984

UniGene: Mm.489807

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