Recombinant Mouse Adenylate cyclase type 3 (Adcy3), partial

1. Cell apoptosis in the testicular tissues of AC3(-/-) mice increased significantly compared with that in wild-type (AC3(+/+)) mice. The expression of 693 genes was altered in the testicular tissues of AC3(-/-) mice, including 330 up-regulated and 363 down-regulated gene expression, helping to elucidate the mechanisms underlying the sterility in AC3(-/-) male mice. PMID: 27864010
2. AC3 may play a role in proximal olfactory signaling and play a role in the regulation of differentially expressed genes in mouse MOE. PMID: 26633363
3. genetic ablation of adenylate cyclase III has drastic, location-dependent effects on cilia architecture in the mouse nose PMID: 26942602
4. Data showed the presence mRNA of obligated downstream components of olfactory receptor signaling adenylyl cyclase 3 and olfactory G protein in the cerebral cortex of the mouse. PMID: 23817016
5. increased Adcy3 activity robustly protect animals from diet-induced metabolic derangements PMID: 25329148
6. Coexpression of serotonin receptor 5HT6 with adenylyl cyclase type III normalizes cilia structure and restores dendrite outgrowth. PMID: 23392690
7. Data suggest that while ADCY3 is responsible for a share of the cAMP in osteoclasts, the reduction of cAMP levels in the absence of this gene is insufficient to augment differentiation or effect changes in bone mass in vivo. PMID: 22985540
8. We conclude that AC3 in the main olfactory epithelium is required for detecting the mechanical force of airflow, which in turn may regulate odorant perception during sniffing. PMID: 23136416
9. In primary culture and in situ in G93A SOD1 mice there is a large reduction in the proportion of motor neurons bearing a primary cilium. PMID: 21767396
10. Maternal behavior was impaired in female mice deficient in adenylyl cyclase 3. PMID: 21150908
11. AC3(-/-) mice show no short-term memory for novel objects and fail to exhibit extinction of contextual fear conditioning PMID: 21490195
12. GSK3beta inactivation or deletion reduces aquaporin 2 expression by modulating adenylate cyclase activity and cAMP generation, thereby impairing responses to vasopressin in the renal collecting duct PMID: 20056751
13. cAMP signals generated by AC3 in the hypothalamus may play a critical role in regulation of body weight PMID: 19750222
14. adenylyl cyclase 3 is functional in rodent oocytes and its activity is involved in the control of oocyte meiotic arrest PMID: 12798295
15. required for normal spermatid or spermatozoa function and male fertility PMID: 15705663
16. point to a major role played by a crucial element of the odorant-induced transduction cascade, adenylyl cyclase 3, in the targeting of olfactory sensory neuron axons towards the brain PMID: 17537788
17. There was robust Adcy3 expression in both olfactory sensory neuron cilia and axons during the period of active glomerular formation in neonatal transgenic mice. PMID: 17581954

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KEGG: mmu:104111

STRING: 10090.ENSMUSP00000020984

UniGene: Mm.489807