Function |
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. |
Gene References into Functions |
- Depletion of miR-34a facilitated endothelial cell growth and blocked apoptosis in AS by upregulating Bcl-2, offering a promising avenue for AS therapy. PMID: 29704100
- BCL-XL promotes stemness and contributes to the aggressiveness of both melanoma and glioblastoma. PMID: 29238043
- targeting BCLxL in human and mouse synovial sarcoma with the small molecule BH3 domain inhibitor, BXI-72, achieved significant cytoreduction and increased apoptotic signaling. PMID: 28851813
- GATA-3 participates in the healing of bone fractures via regulating bcl-xL gene expression, owing to its association with Runx2. PMID: 29170477
- this study demonstrates that necrosis of Mycobacterium tuberculosis-infected macrophages is dependent on the action of Bcl-xl PMID: 28401933
- Mitochondrial Bcl-xL is involved in maintaining mitochondrial respiratory capacity. Its deficiency causes oxidative stress, which is associated with an increased glycolytic capacity and balanced by an increased activity of the pentose phosphate pathway. PMID: 28807815
- Proapoptotic proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL. PMID: 28682312
- BMP4 promotes survival of neural stem/progenitor cells by enhancing the anti-apoptotic function of Bcl-xL via BMP4-Smad1/5/8-Id1 signaling in the presence of FGF-2. PMID: 29353044
- Bcl-xL is required for survival of post mitotic neurons throughout the developing spinal cord. PMID: 27665712
- Atherosclerosis-associated endothelial cell apoptosis may partially result from downregulation of Bcl-Xl, through upregulation of miR-876 that binds and suppresses translation of Bcl-Xl mRNA. PMID: 28723693
- Bcl-xL is a driver in colorectal tumorigenesis and cancer progression. PMID: 27537525
- These data show that Mcl-1 is dispensable for the regulation of apoptosis during infection with different large DNA viruses.Bcl-XL, on the other hand, can be important to maintain survival of virus-infected cells PMID: 27537523
- BCL-XL expression promotes survival of immature B cells, expression of BCL-2 is important for survival of mature B cells and long-lived plasma cells (PC), and expression of MCL-1 is important for survival throughout B-cell development. PMID: 27560714
- Bcl-xL deficiency induced apoptosis in a select population of differentiated neurons and led to severe neurobehavioral abnormalities. PMID: 27194326
- loss of PUMA had no impact on the loss of platelets caused by loss of BCL-XL. It therefore remains to be established whether other BH3-only proteins play a critical role in induction of apoptosis in platelets or whether their death is controlled solely by the interactions between BCL-XL with BAK and BAX. PMID: 27221652
- MLF1 is negatively regulated by 14-3-3 via binding to, and blocking, MLF1's Bcl-2 homology domain 3 and thereby preventing Bcl-XL from associating with MLF1. PMID: 26563351
- Genetic and pharmacological inhibition of BCL-W and BCL-XL causes directed elimination of senescent cells. PMID: 27048913
- Valproic acid sensitized TRAIL-resistant papillary thyroid carcinoma cells to apoptotic cell death through involvement of Nrf2 and Bcl-xL. PMID: 26721202
- These findings indicate that eosinophil survival is largely regulated by betac chain-induced NF-kappaB activation and subsequent induction of Bcl-x PMID: 25862560
- these data indicate that beta-cell apoptosis is, in part, attributable to the modulation of 5'SS selection in the Bcl-x pre-mRNA by bioactive lipids modulated by iPLA2beta. PMID: 25762722
- only loss of both Bclx alleles markedly forestalled tumorigenesis, loss of a single Bim allele overcame this blockade. PMID: 24858047
- analysis of the role of BCL-XL or MCL-1 in the development and sustained growth of thymic lymphoma elicited by loss of p53 reveals that only MCL-1 is critical PMID: 25368374
- cell death is C/EBP homologous protein (CHOP)-dependent, connecting these events to the UPR. Thus plasma cell differentiation proceeds through a Bcl-xL-dependent intermediate. PMID: 25023286
- These results demonstrate that Bcl-xL regulates CD1d-mediated Ag processing and presentation to NKT cells by altering the late endosomal compartment and changing the intracellular localization of CD1d. PMID: 25070854
- anti-apoptotic role of HAX-1 versus BCL-XL in cytokine-dependent bone marrow-derived cells PMID: 24910348
- IL-33/ST2 axis promotes mast cell survival via BCLXL. PMID: 24982172
- PP6 activity is regulated to control apoptosis by modulating Ser(62) phosphorylation of Bcl-xL, which results in its polyubiquitination and degradation. PMID: 24808369
- signaling cassette identified in cardiac myocytes consisting of K-Ras, RASSF1A and Mst1 localized to mitochondria; promotes Mst1 activation in response to oxidative stress; activated Mst1 phosphorylates Bcl-xL antagonizing Bcl-xL-Bax binding causing activation of Bax and subsequent apoptosis PMID: 24813943
- A double-mutant knockin of the CD28 YMNM and PYAP motifs reveals a critical role for the YMNM motif in regulation of T cell proliferation and Bcl-xL expression. PMID: 24639356
- Instead, Bcl-xL -blocked apoptosis resulting from hypoxia and/or nutrient loss associated with the inhibition of angiogenesis caused by NK cell-secreted IFN-gamma PMID: 24313893
- identified inositol trisphosphate receptors as unique effectors of K-Ras4B that antagonize the prosurvival signals of other K-Ras effectors. PMID: 24297914
- Disruption of Bcl-xL:Bax binding caused rapid apoptosis of neural progenitors and medulloblastoma cells. PMID: 24227720
- Bcl-xL interacts functionally with VDAC1 and -3 but not VDAC2. PMID: 23720737
- Cleavage-resistant Bcl-2 and Bcl-xL are more efficient than their wild-type counterparts at inhibiting apoptosis in primary mouse T cells after T cell receptor cross-linking mechanisms. PMID: 23203923
- In steatotic hepatocytes, the lack of voltage-dependent anion channel phosphorylation is accompanied by a decrease of interaction with the serine/threonine glycogen synthase kinase 3 and Bcl-XL in mitochondria. PMID: 22814966
- Bcl-xL has crucial anti-apoptotic roles at multistages in the megakaryocytic lineage, making possible prevention of lethal or severe spontaneous hemorrhage. PMID: 22790873
- Hesperetin prevented the xenograft growth by down-regulating the expression of cyclin D1, CDK4 and Bcl-xL and up-regulating p57Kip2 expression in MCF-7 cells. PMID: 22209285
- Clusterin interacts with Bcl-xL in dying hippocampal CA3 neurons following seizures while the levels of Bcl-xL remain constant. PMID: 22197644
- BCL-X is required for survival of differentiating retinal ganglion cells. PMID: 22836101
- when localalized in the endoplasmic reticulum, Bcl-x(L) impinges on Ca(2+) homeostasis but does not affect apoptosis unless Bcl-x(L) is present in additional cellular compartments. PMID: 22573883
- Tanshinone IIA protected neurons against the Abeta-induced cytotoxicity most likely via activation of the Bcl-xL pathway PMID: 22498308
- The combination of Bcl-x(L) and Mcl-1 is essential for the viability of the megakaryocyte lineage. PMID: 22374700
- Modulation of macrophage resistance to apoptosis through targeted deletion of Bcl-x has a major impact on the entire macrophage cell population in the body PMID: 22383704
- The Bcl-2 proteins Noxa and Bcl-xL co-ordinately regulate oxidative stress-induced apoptosis. PMID: 22380599
- Pathologic elevation of Bcl-x(L) may be the result of impaired adaptation, with implications for myeloproliferative disease mechanisms. PMID: 22086418
- Data show that Down syndrome model mice ehxibit downregulation of Bcl-X(L) in the hippocampus. PMID: 21684326
- Hematopoietic stem cells in patients with an Lnk/Sh2b3 mutation might become resistant to apoptosis due to thrombopoietin-mediated enhanced expression of Bcl-xL. PMID: 22101255
- Bcl-xL is required for lymphomagenesis in myc(-/-) transgenic mice, who constitutively overexpress c-Myc oncoprotein in B-lymphoid cells and develop pre-B and B-cell lymphomas; this is in contrast to Bcl-2 which is required. PMID: 21998213
- EVI1 directly induces the expression of Bcl-xL through the first set of zinc finger and thereby inhibits apoptosis PMID: 21980434
- Hrk deficiency does not significantly attenuate the widespread apoptosis seen in the Bcl-x (-/-) embryonic nervous system, indicating that other BH3-only molecules, alone or in combination, may regulate BAX activation in immature neurons. PMID: 22043021
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Subcellular Location |
Mitochondrion membrane, Single-pass membrane protein, Nucleus membrane, Single-pass membrane protein, Cytoplasmic side, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Note=Localizes to the centrosome when phosphorylated at Ser-49, SUBCELLULAR LOCATION: Isoform Bcl-X(L): Mitochondrion inner membrane, Mitochondrion outer membrane, Mitochondrion matrix, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Cytoplasm, cytosol |
Protein Families |
Bcl-2 family |
Tissue Specificity |
Widely expressed, with highest levels in the brain, thymus, bone marrow, and kidney. Bcl-X(L) and Bcl-X(delta-TM) expression is enhanced in B- and T-lymphocytes that have been activated. |
Database Links |
KEGG: mmu:12048 STRING: 10090.ENSMUSP00000007803 UniGene: Mm.238213 |