Recombinant Mouse Bcl-2-like protein 1(Bcl2l1) ,partial

Code CSB-YP731050MO1
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Source Yeast
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Code CSB-EP731050MO1
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Source E.coli
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Code CSB-EP731050MO1-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP731050MO1
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Source Baculovirus
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Code CSB-MP731050MO1
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Bcl2l1
Uniprot No. Q64373
Alternative Names Bcl2l1; Bcl2l; Bclx; Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X
Species Mus musculus (Mouse)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Gene References into Functions
  1. Depletion of miR-34a facilitated endothelial cell growth and blocked apoptosis in AS by upregulating Bcl-2, offering a promising avenue for AS therapy. PMID: 29704100
  2. BCL-XL promotes stemness and contributes to the aggressiveness of both melanoma and glioblastoma. PMID: 29238043
  3. targeting BCLxL in human and mouse synovial sarcoma with the small molecule BH3 domain inhibitor, BXI-72, achieved significant cytoreduction and increased apoptotic signaling. PMID: 28851813
  4. GATA-3 participates in the healing of bone fractures via regulating bcl-xL gene expression, owing to its association with Runx2. PMID: 29170477
  5. this study demonstrates that necrosis of Mycobacterium tuberculosis-infected macrophages is dependent on the action of Bcl-xl PMID: 28401933
  6. Mitochondrial Bcl-xL is involved in maintaining mitochondrial respiratory capacity. Its deficiency causes oxidative stress, which is associated with an increased glycolytic capacity and balanced by an increased activity of the pentose phosphate pathway. PMID: 28807815
  7. Proapoptotic proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL. PMID: 28682312
  8. BMP4 promotes survival of neural stem/progenitor cells by enhancing the anti-apoptotic function of Bcl-xL via BMP4-Smad1/5/8-Id1 signaling in the presence of FGF-2. PMID: 29353044
  9. Bcl-xL is required for survival of post mitotic neurons throughout the developing spinal cord. PMID: 27665712
  10. Atherosclerosis-associated endothelial cell apoptosis may partially result from downregulation of Bcl-Xl, through upregulation of miR-876 that binds and suppresses translation of Bcl-Xl mRNA. PMID: 28723693
  11. Bcl-xL is a driver in colorectal tumorigenesis and cancer progression. PMID: 27537525
  12. These data show that Mcl-1 is dispensable for the regulation of apoptosis during infection with different large DNA viruses.Bcl-XL, on the other hand, can be important to maintain survival of virus-infected cells PMID: 27537523
  13. BCL-XL expression promotes survival of immature B cells, expression of BCL-2 is important for survival of mature B cells and long-lived plasma cells (PC), and expression of MCL-1 is important for survival throughout B-cell development. PMID: 27560714
  14. Bcl-xL deficiency induced apoptosis in a select population of differentiated neurons and led to severe neurobehavioral abnormalities. PMID: 27194326
  15. loss of PUMA had no impact on the loss of platelets caused by loss of BCL-XL. It therefore remains to be established whether other BH3-only proteins play a critical role in induction of apoptosis in platelets or whether their death is controlled solely by the interactions between BCL-XL with BAK and BAX. PMID: 27221652
  16. MLF1 is negatively regulated by 14-3-3 via binding to, and blocking, MLF1's Bcl-2 homology domain 3 and thereby preventing Bcl-XL from associating with MLF1. PMID: 26563351
  17. Genetic and pharmacological inhibition of BCL-W and BCL-XL causes directed elimination of senescent cells. PMID: 27048913
  18. Valproic acid sensitized TRAIL-resistant papillary thyroid carcinoma cells to apoptotic cell death through involvement of Nrf2 and Bcl-xL. PMID: 26721202
  19. These findings indicate that eosinophil survival is largely regulated by betac chain-induced NF-kappaB activation and subsequent induction of Bcl-x PMID: 25862560
  20. these data indicate that beta-cell apoptosis is, in part, attributable to the modulation of 5'SS selection in the Bcl-x pre-mRNA by bioactive lipids modulated by iPLA2beta. PMID: 25762722
  21. only loss of both Bclx alleles markedly forestalled tumorigenesis, loss of a single Bim allele overcame this blockade. PMID: 24858047
  22. analysis of the role of BCL-XL or MCL-1 in the development and sustained growth of thymic lymphoma elicited by loss of p53 reveals that only MCL-1 is critical PMID: 25368374
  23. cell death is C/EBP homologous protein (CHOP)-dependent, connecting these events to the UPR. Thus plasma cell differentiation proceeds through a Bcl-xL-dependent intermediate. PMID: 25023286
  24. These results demonstrate that Bcl-xL regulates CD1d-mediated Ag processing and presentation to NKT cells by altering the late endosomal compartment and changing the intracellular localization of CD1d. PMID: 25070854
  25. anti-apoptotic role of HAX-1 versus BCL-XL in cytokine-dependent bone marrow-derived cells PMID: 24910348
  26. IL-33/ST2 axis promotes mast cell survival via BCLXL. PMID: 24982172
  27. PP6 activity is regulated to control apoptosis by modulating Ser(62) phosphorylation of Bcl-xL, which results in its polyubiquitination and degradation. PMID: 24808369
  28. signaling cassette identified in cardiac myocytes consisting of K-Ras, RASSF1A and Mst1 localized to mitochondria; promotes Mst1 activation in response to oxidative stress; activated Mst1 phosphorylates Bcl-xL antagonizing Bcl-xL-Bax binding causing activation of Bax and subsequent apoptosis PMID: 24813943
  29. A double-mutant knockin of the CD28 YMNM and PYAP motifs reveals a critical role for the YMNM motif in regulation of T cell proliferation and Bcl-xL expression. PMID: 24639356
  30. Instead, Bcl-xL -blocked apoptosis resulting from hypoxia and/or nutrient loss associated with the inhibition of angiogenesis caused by NK cell-secreted IFN-gamma PMID: 24313893
  31. identified inositol trisphosphate receptors as unique effectors of K-Ras4B that antagonize the prosurvival signals of other K-Ras effectors. PMID: 24297914
  32. Disruption of Bcl-xL:Bax binding caused rapid apoptosis of neural progenitors and medulloblastoma cells. PMID: 24227720
  33. Bcl-xL interacts functionally with VDAC1 and -3 but not VDAC2. PMID: 23720737
  34. Cleavage-resistant Bcl-2 and Bcl-xL are more efficient than their wild-type counterparts at inhibiting apoptosis in primary mouse T cells after T cell receptor cross-linking mechanisms. PMID: 23203923
  35. In steatotic hepatocytes, the lack of voltage-dependent anion channel phosphorylation is accompanied by a decrease of interaction with the serine/threonine glycogen synthase kinase 3 and Bcl-XL in mitochondria. PMID: 22814966
  36. Bcl-xL has crucial anti-apoptotic roles at multistages in the megakaryocytic lineage, making possible prevention of lethal or severe spontaneous hemorrhage. PMID: 22790873
  37. Hesperetin prevented the xenograft growth by down-regulating the expression of cyclin D1, CDK4 and Bcl-xL and up-regulating p57Kip2 expression in MCF-7 cells. PMID: 22209285
  38. Clusterin interacts with Bcl-xL in dying hippocampal CA3 neurons following seizures while the levels of Bcl-xL remain constant. PMID: 22197644
  39. BCL-X is required for survival of differentiating retinal ganglion cells. PMID: 22836101
  40. when localalized in the endoplasmic reticulum, Bcl-x(L) impinges on Ca(2+) homeostasis but does not affect apoptosis unless Bcl-x(L) is present in additional cellular compartments. PMID: 22573883
  41. Tanshinone IIA protected neurons against the Abeta-induced cytotoxicity most likely via activation of the Bcl-xL pathway PMID: 22498308
  42. The combination of Bcl-x(L) and Mcl-1 is essential for the viability of the megakaryocyte lineage. PMID: 22374700
  43. Modulation of macrophage resistance to apoptosis through targeted deletion of Bcl-x has a major impact on the entire macrophage cell population in the body PMID: 22383704
  44. The Bcl-2 proteins Noxa and Bcl-xL co-ordinately regulate oxidative stress-induced apoptosis. PMID: 22380599
  45. Pathologic elevation of Bcl-x(L) may be the result of impaired adaptation, with implications for myeloproliferative disease mechanisms. PMID: 22086418
  46. Data show that Down syndrome model mice ehxibit downregulation of Bcl-X(L) in the hippocampus. PMID: 21684326
  47. Hematopoietic stem cells in patients with an Lnk/Sh2b3 mutation might become resistant to apoptosis due to thrombopoietin-mediated enhanced expression of Bcl-xL. PMID: 22101255
  48. Bcl-xL is required for lymphomagenesis in myc(-/-) transgenic mice, who constitutively overexpress c-Myc oncoprotein in B-lymphoid cells and develop pre-B and B-cell lymphomas; this is in contrast to Bcl-2 which is required. PMID: 21998213
  49. EVI1 directly induces the expression of Bcl-xL through the first set of zinc finger and thereby inhibits apoptosis PMID: 21980434
  50. Hrk deficiency does not significantly attenuate the widespread apoptosis seen in the Bcl-x (-/-) embryonic nervous system, indicating that other BH3-only molecules, alone or in combination, may regulate BAX activation in immature neurons. PMID: 22043021

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Subcellular Location Mitochondrion membrane, Single-pass membrane protein, Nucleus membrane, Single-pass membrane protein, Cytoplasmic side, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Note=Localizes to the centrosome when phosphorylated at Ser-49, SUBCELLULAR LOCATION: Isoform Bcl-X(L): Mitochondrion inner membrane, Mitochondrion outer membrane, Mitochondrion matrix, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Cytoplasm, cytosol
Protein Families Bcl-2 family
Tissue Specificity Widely expressed, with highest levels in the brain, thymus, bone marrow, and kidney. Bcl-X(L) and Bcl-X(delta-TM) expression is enhanced in B- and T-lymphocytes that have been activated.
Database Links

KEGG: mmu:12048

STRING: 10090.ENSMUSP00000007803

UniGene: Mm.238213

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