Recombinant Mouse G1/S-specific cyclin-D3(Ccnd3)

Code CSB-YP004814MO
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Source Yeast
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Code CSB-EP004814MO
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Source E.coli
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Code CSB-EP004814MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP004814MO
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Source Baculovirus
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Code CSB-MP004814MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Ccnd3
Uniprot No. P30282
Alternative Names Ccnd3; Cyl-3; G1/S-specific cyclin-D3
Species Mus musculus (Mouse)
Expression Region 1-292
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Gene References into Functions
  1. These results suggest that progesterone receptor overexpression in endometrial stromal cells, likely due to high progesterone levels, triggers cyclin D3 and Hoxa-10 overexpression, which may be involved in the pathological mechanisms of the mouse uterine decidual reaction. PMID: 27511308
  2. the activation of TLR7 increased CCND3 expression via the downregulation of miR-15b in B cells. PMID: 26144250
  3. immature B and T cells use lymphocyte lineage- and developmental stage-specific mechanisms to inhibit Cyclin D3 protein levels. PMID: 27327568
  4. we suggest that proper regional decidualization and polyploidy development requires FoxM1 signaling downstream of Hoxa10 and cyclin D3. PMID: 26350477
  5. DYRK1A has a role in lymphopoiesis; Cyclin D3 protein stability is negatively regulated during exit from the proliferative phases of B and T cell development PMID: 26008897
  6. inactivation of Ccnd3 leads to increased frequencies of lymphocytes with biallelic expression of IgH or TCRbeta genes. PMID: 25127855
  7. Results indicate that cyclin D3 plays a cell-autonomous and nonredundant function in regulating the dynamic balance between proliferation, differentiation, and self-renewal that normally establishes an appropriate pool size of adult satellite cells. PMID: 23897741
  8. Investigated the expression of GABA and GABPR in the early-pregnancy mouse uterus. Cyclin D3 was measured in cultured stromal cells artificially induced to undergo decidualization, by GABA and a GABA A-type receptor agonist or antagonist. PMID: 23150429
  9. Subnuclear compartmentalization enables cyclin D3 to drive cell cycle progression and repress V gene accessibility, thereby ensuring coordination of proliferation with immunoglobulin recombination. PMID: 23109711
  10. cyclin D3 expression influences a host of genes involved in decidualization and can improve decidualization in Hoxa-10(-/-) mice. PMID: 23008516
  11. CCND3 gene product cyclin D3 regulates the number of cell divisions that erythroid precursors undergo during terminal differentiation PMID: 22929040
  12. Cyclin D3 primes myoblasts for differentiation by enhancing muscle specific gene expression and cell cycle exit. PMID: 21898542
  13. Ccnd3(-/-) mice exhibit a B-cell-intrinsic defect in germinal center maturation and fail to generate an affinity-matured IgG response. The defect resulted from failed proliferative expansion of GL7(+) IgD(-) PNA(+) B cells. PMID: 20956554
  14. coordinate expression and functional association of cyclin D3 with cdk4 suggest a role for proliferation and, that of cyclin D3 with p21 and cdk6 is consistent with the development of polyploidy during stromal cell decidualization PMID: 11804782
  15. cyclin D3 expression is regulated through different pathways and plays a distinct role in the liver PMID: 12085346
  16. cyclin D3-cdk4 activity represses skeletal muscle differentiation by blocking the association of MEF2 with the coactivator GRIP-1 and concomitantly disrupts the associateion of these factors with punctate nuclear subdomains within the cell PMID: 12130539
  17. Overexpression of both Cdk6 & D3 enhances susceptibility of BALB/c3T3 & C3H10T1/2 mouse fibroblast lines to UV radiation & 3-methylcholanthrene transformation. Deregulated expression of Cdk6 & cyclin D3 may predispose cells to malignant transformation. PMID: 12592386
  18. knock-down of cyclin D3 inhibited proliferation of acute lymphoblastic leukemias deriving from immature T lymphocytes PMID: 14706337
  19. Cdk6-cyclin D3 complexes are not subject to inhibition by p16(INK4a) PMID: 14724578
  20. cyclin d3 does not have a role in regulating AML1/RUNX1 increase during G1 to S cell cycle progression PMID: 14747476
  21. cyclin D3 is an important factor governing adipogenesis and obesity through activation of peroxisome proliferator-activated receptor gamma PMID: 16260612
  22. Cyclin D3 is increased during differentiation and phosphorylates C/EBPalpha at Ser193, leading to the formation of growth-inhibitory C/EBPalpha-cdk2 and C/EBPalpha-Brm complexes. PMID: 16537903
  23. Cyclin D3 plays a key role in normal B-1a lymphocyte mitogenesis. PMID: 16818732
  24. Results demonstrate that cyclin D3 is an essential cell cycle recipient of G-CSF signaling, and provide a molecular link of how G-CSF-dependent signaling triggers cell proliferation. PMID: 16954383
  25. identification of cyclin D3 as a novel binding partner of lamin A/C has important implications for a role for lamin A/C in muscle differentiation PMID: 17321498
  26. These results indicate that the pRb-dependent accumulation of cyclin D3 is functionally relevant to the process of skeletal muscle cell differentiation. PMID: 17709384
  27. These results provide, at least in part, an explanation for the defective small decidua of mice lacking the Il11ra gene, and reveal for the first time that cyclin D3, CDKN1A (p21), and BIRC5 (Survivin) are targets of IL11 in the decidua. PMID: 17881769
  28. A new HDAC5 target is identified: the gene encoding the cell cycle-regulatory protein cyclin D3. PMID: 18404677
  29. Inhibition of PLCbeta1 activity prevents the upregulation of cyclinD3 and cdk4 protein, suggesting that PLCbeta1 plays a role in the control of the cell cycle during differentiation. PMID: 19385066
  30. pre-BCR-mediated activation of the Ras-MEK-Erk signaling pathway silenced transcription of Ccnd3 and coordinated exit from the cell cycle with induction of the transcription factor E2A PMID: 19734904
  31. Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest. PMID: 8668211

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Subcellular Location Nucleus, Cytoplasm, Membrane
Protein Families Cyclin family, Cyclin D subfamily
Database Links

KEGG: mmu:12445

STRING: 10090.ENSMUSP00000040488

UniGene: Mm.27291


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