CCND3 Research Reagents

G1/S-specific cyclin-D3is a protein in humans that is encoded by CCND3 gene. Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity.

The following CCND3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CCND3 Antibodies

CCND3 Antibodies for Homo sapiens (Human)

CCND3 Proteins

CCND3 Proteins for Mus musculus (Mouse)

CCND3 Proteins for Homo sapiens (Human)

CCND3 Proteins for Rattus norvegicus (Rat)

CCND3 Proteins for Bos taurus (Bovine)

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