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| Code | CSB-EP006562MO1b3 |
| Product Type | Recombinant Protein |
| Size | US$2466 |
| Uniprot No. | P29812 |
| Relevance | Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA) (PubMed:1537333). Involved in regulating eumelanin and phaeomelanin levels. |
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| Storage Buffer | Tris-based buffer,50% glycerol |
| Alias | DOPAchrome conversion factor1 Publication DOPAchrome isomerase1 Publication DOPAchrome oxidoreductase1 Publication L-dopachrome Delta-isomerase SLATY locus protein Tyrosinase-related protein 2 |
| Species | Mus musculus (Mouse) |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Sequence | QFPRVCMTLDGVLNKECCPPLGPEATNICGFLEGRGQCAEVQTDTRPWSGPYILRNQDDREQWPRKFFNRTCKCTGNFAGYNCGGCKFGWTGPDCNRKKPAILRRNIHSLTAQEREQFLGALDLAKKSIHPDYVITTQHWLGLLGPNGTQPQIANCSVYDFFVWLHYYSVRDTLLGPGRPYKAIDFSHQGPAFVTWHRYHLLWLERELQRLTGNESFALPYWNFATGKNECDVCTDELLGAARQDDPTLISRNSRFSTWEIVCDSLDDYNRRVTLCNGTYEGLLRRNKVGRNNEKLPTLKNVQDCLSLQKFDSPPFFQNSTFSFRNALEGFDKADGTLDSQVMNLHNLAHSFLNGTNALPHSAANDPVFVVLHSFTDAIFDEWLKRNNPSTDAWPQELAPIGHNRMYNMVPFFPPVTNEELFLTAEQLGYNYAVDLSEEEAPVWSTTLS |
| Research Area | others |
| Source | E.coli |
| Gene Names | Dct |
| Expression Region | 24-472aa |
| Tag Info | N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged |
| Mol. Weight | 71.2kDa |
| Protein Description | Partial |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA) |
| Involvement in disease | The slaty mutation in Tyrp2 leads to a decrease of DT activity and a consequent change in the pigmentation of the mice to a dark gray/brown eumelanin. The slaty-2j mutation has a similar phenotype, the slaty-lt (light) mutation has a more severe effect and is semidominant; its phenotype may be a result of the failure of the enzyme to be correctly targeted to its normal location on the inner face of the melanosomal membrane. |
| Subcellular Location | Melanosome membrane, Single-pass type I membrane protein, Melanosome |
| Protein Families | Tyrosinase family |
| Tissue Specificity | Melanocytes and retinal pigmented epithelium. |
| Database Links |
KEGG: mmu:13190 STRING: 10090.ENSMUSP00000022725 UniGene: Mm.19987 |
| Pathway | Melanogenesis |
Dct Antibodies for Mus musculus (Mouse)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA006562ZA01MO | Dct Antibody | Mus musculus | ELISA, WB (ensure identification of antigen) |
| CSB-PA006562ZA01MO | Dct Antibody | Mus musculus | ELISA, WB (ensure identification of antigen) |
Dct Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP006562MO1 CSB-BP006562MO1 CSB-MP006562MO1 |
Recombinant Mouse L-dopachrome tautomerase(Dct), partial | Yeast Baculovirus Mammalian cell |
| CSB-CF006562MO | Recombinant Mouse L-dopachrome tautomerase(Dct) | in vitro E.coli expression system |
| CSB-EP006562MO1 | Recombinant Mouse L-dopachrome tautomerase(Dct),partial | E.coli |
Recombinant Human TAR DNA-binding protein 43(TARDBP),partial
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Transcriptional enhancer factor TEF-1(TEAD1)
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Steroid 21-hydroxylase(CYP21A2)
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Pig Epididymal secretory glutathione peroxidase(GPX5)
Express system: E.coli
Species: Sus scrofa (Pig)
Recombinant Human Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial(GATC)
Express system: E.coli
Species: Homo sapiens (Human)
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